公开(公告)号：US4136188A

公开(公告)日：1979-01-23

申请号：US699761

申请日：1976-06-25

申请人： Fumiyoshi Ishikawa ,  Akira Kosasayama ,  Yoshifumi Watanabe ,  Yasushi Abiko ,  Kin-Ya Kameda ,  Shin-etu Ono

发明人： Fumiyoshi Ishikawa ,  Akira Kosasayama ,  Yoshifumi Watanabe ,  Yasushi Abiko ,  Kin-Ya Kameda ,  Shin-etu Ono

IPC分类号： C07D233/06 ,  C07D233/48 ,  C07D235/02 ,  C07D239/06 ,  C07D239/14 ,  C07D243/04 ,  A61K31/415

CPC分类号： C07D235/02 ,  C07D233/06 ,  C07D233/48 ,  C07D239/06 ,  C07D239/14 ,  C07D243/04 ,  Y10S514/866

摘要： 2-SUBSTITUTED-1,3-DIAZACYCLIC COMPOUNDS OF THE FORMULA: ##STR1## wherein R.sub.1 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R.sub.2 represents a hydrogen atom, a lower alkoxycarbonyl group, an aliphatic acyl group or an aromatic acyl group, the aromatic ring of which may have one or more substituents selected from a halogen atom, a lower alkyl group, a lower alkoxy group, an acyl group and an acyloxy group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower hydroxyalkyl group or an aralkyl group; R.sub.4 represents a hydrogen atom, a lower alkyl group or an aryl group; R.sub.6 represents a cyclohexyl group, a pyridyl group or a phenyl group which may have a substituent selected from a halogen atom, a lower alkyl group and a lower alkoxy group; A represents -N.dbd., an -N(lower alkyl)- group or a methylene group; n represents an integer of from 2 to 4, and a dotted line indicates that a double bond is optional; salts of such derivatives; and the method for preparing such compounds and their salts; the compounds and their salts having a distinct anti-diabetic activity in humans and animals.

公开(公告)号：US4138491A

公开(公告)日：1979-02-06

申请号：US809814

申请日：1977-06-24

申请人： Fumiyoshi Ishikawa ,  Akira Kosasayama ,  Yoshifumi Watanabe ,  Yasushi Abiko ,  Kin-ya Kameda ,  Shin-etu Ono

发明人： Fumiyoshi Ishikawa ,  Akira Kosasayama ,  Yoshifumi Watanabe ,  Yasushi Abiko ,  Kin-ya Kameda ,  Shin-etu Ono

IPC分类号： A61K31/415 ,  A61K31/44 ,  A61K31/4427 ,  A61P3/08 ,  A61P3/10 ,  A61P7/02 ,  C07D233/06 ,  C07D233/20 ,  C07D401/06

CPC分类号： C07D233/06 ,  Y10S514/866

摘要： A method for treating diabetes comprising administering a therapeutically effective amount of a 2-(2,2-disubstituted)ethylimidazoline of the general formula (I) ##STR1## wherein R is a phenyl group or a 2-pyridyl group or the pharmaceutically acceptable acid addition salts thereof, to a patient having diabetes.

摘要翻译： 一种治疗糖尿病的方法，其包括施用治疗有效量的通式（I）的2-（2,2-二取代的）乙基咪唑啉其中R是苯基或2-吡啶基或 可药用的酸加成盐给患有糖尿病的患者。