公开(公告)号：US07858112B2

公开(公告)日：2010-12-28

申请号：US10372957

申请日：2003-02-26

申请人： Tomio Hatanaka ,  Rui Saito ,  Kenji Sugibayashi ,  Kiyose Nakagawa

发明人： Tomio Hatanaka ,  Rui Saito ,  Kenji Sugibayashi ,  Kiyose Nakagawa

IPC分类号： A61K9/70

CPC分类号： A61K9/703 ,  A61K9/7084

摘要： The present invention provides a percutaneous absorption system and a percutaneous absorption method, which have a simple constitution and can realize the easy and continuous percutaneous absorption of medicine even when the medicine is formed of a water-soluble oligomer solution or a high-molecular solution. In the percutaneous absorption system comprising a medicine reservoir portion having a medicine holding portion which holds medicine therein and a support portion for supporting the medicine reservoir portion, the support portion including an adhesive layer and a substrate having medicine non-permeating property, the system is provided with an elastic member for applying pressure to the medicine held in the inside of the medicine reservoir portion, and by breaking the substrate having medicine non-permeating property in the support portion using a mechanical stimulus such as an injection needle or the like, the medicine is released (delivered) at a fixed rate.

摘要翻译： 本发明提供一种具有简单结构的经皮吸收系统和经皮吸收方法，即使药物由水溶性低聚物溶液或高分子溶液形成，也能实现药物的容易且连续的经皮吸收。 在包含药剂贮存部的药皮吸收系统中，所述药剂储存部具有保持药剂的药剂保持部和用于支持药剂贮存部的支撑部，所述支撑部包括粘合剂层和具有药物不渗透性的基材， 设置有用于对保持在药剂储存部内部的药物施加压力的弹性部件，并且通过使用诸如注射针等的机械刺激来破坏在支撑部分中具有药物不渗透性的基底， 医药以固定的价格发放（交付）。