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    Assays and methods using biomarkers
    1.
    发明授权
    Assays and methods using biomarkers 有权
    使用生物标志物的测定和方法

    公开(公告)号：US07629136B2

    公开(公告)日：2009-12-08

    申请号：US11542318

    申请日：2006-10-03

    申请人： Avi J. Ashkenazi ,  Klaus W. Wagner

    发明人： Avi J. Ashkenazi ,  Klaus W. Wagner

    IPC分类号： G01N33/53 ,  C12Q1/68

    CPC分类号： A61K38/1709 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/91091 ,  G01N2510/00 ,  G01N2800/24

    摘要： Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.

    摘要翻译： 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定，检测一种或多种此类生物标志物的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L / TRAIL和抗DR5激动剂抗体敏感。 可以检查的某些生物标志物包括岩藻糖基转移酶，特别是岩藻糖基转移酶3（FUT3）和/或岩藻糖基转移酶6（FUT6）以及唾液酸基路易斯A和/或X抗原。 还提供了工具包和制品。

    ASSAYS AND METHODS USING BIOMARKERS
    2.
    发明申请
    ASSAYS AND METHODS USING BIOMARKERS 审中-公开
    使用生物标记的测定和方法

    公开(公告)号：US20120328603A1

    公开(公告)日：2012-12-27

    申请号：US13303638

    申请日：2011-11-23

    申请人： Avi J. Ashkenazi ,  Klaus W. Wagner

    发明人： Avi J. Ashkenazi ,  Klaus W. Wagner

    IPC分类号： C12Q1/68 ,  C40B30/04 ,  A61N5/10 ,  A61P37/00 ,  A61P35/00 ,  G01N33/574 ,  A61K39/395

    CPC分类号： G01N33/573 ,  C07K16/2878 ,  C07K16/2896 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N2333/91091 ,  G01N2333/91097 ,  G01N2510/00

    摘要： Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.

    摘要翻译： 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定，检测一种或多种此类生物标志物的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L / TRAIL和抗DR5激动剂抗体敏感。 可以检查的某些生物标志物包括岩藻糖基转移酶，特别是岩藻糖基转移酶3（FUT3）和/或岩藻糖基转移酶6（FUT6）以及唾液酸基路易斯A和/或X抗原。 还提供了工具包和制品。

    Assays and methods using biomarkers
    3.
    发明申请
    Assays and methods using biomarkers 有权
    使用生物标志物的测定和方法

    公开(公告)号：US20100158856A1

    公开(公告)日：2010-06-24

    申请号：US12589497

    申请日：2009-10-23

    申请人： Avi J. Ashkenazi ,  Klaus W. Wagner

    发明人： Avi J. Ashkenazi ,  Klaus W. Wagner

    IPC分类号： A61K38/19 ,  A61P35/00

    CPC分类号： A61K38/1709 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/91091 ,  G01N2510/00 ,  G01N2800/24

    摘要： Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.

    摘要翻译： 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定，检测一种或多种此类生物标志物的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L / TRAIL和抗DR5激动剂抗体敏感。 可以检查的某些生物标志物包括岩藻糖基转移酶，特别是岩藻糖基转移酶3（FUT3）和/或岩藻糖基转移酶6（FUT6）以及唾液酸基路易斯A和/或X抗原。 还提供了工具包和制品。

    Assays and methods using biomarkers
    7.
    发明授权
    Assays and methods using biomarkers 有权
    使用生物标志物的测定和方法

    公开(公告)号：US08124339B2

    公开(公告)日：2012-02-28

    申请号：US12589497

    申请日：2009-10-23

    申请人： Avi J. Ashkenazi ,  Klaus W. Wagner

    发明人： Avi J. Ashkenazi ,  Klaus W. Wagner

    IPC分类号： C12Q1/68 ,  A61K39/385

    CPC分类号： A61K38/1709 ,  C12Q1/48 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/573 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/6863 ,  G01N33/6893 ,  G01N2333/91091 ,  G01N2510/00 ,  G01N2800/24

    摘要： Methods and assays examining expression of one or more biomarkers in a mammalian tissue or cell sample are provided. According to the disclosed methods and assays, detection of the expression of one or more such biomarkers is predictive or indicative that the tissue or cell sample will be sensitive to apoptosis-inducing agents such as Apo2L/TRAIL and anti-DR5 agonist antibodies. Certain biomarkers which may be examined include fucosyltransferases, in particular fucosyltransferase 3 (FUT3) and/or fucosyltransferase 6 (FUT6), as well as sialyl Lewis A and/or X antigens. Kits and articles of manufacture are also provided.

    摘要翻译： 提供检查哺乳动物组织或细胞样品中一种或多种生物标志物的表达的方法和试验。 根据所公开的方法和测定，检测一种或多种此类生物标志物的表达是预测或指示组织或细胞样品对凋亡诱导剂如Apo2L / TRAIL和抗DR5激动剂抗体敏感。 可以检查的某些生物标志物包括岩藻糖基转移酶，特别是岩藻糖基转移酶3（FUT3）和/或岩藻糖基转移酶6（FUT6）以及唾液酸基路易斯A和/或X抗原。 还提供了工具包和制品。