公开(公告)号：US20130253204A1

公开(公告)日：2013-09-26

申请号：US13991024

申请日：2011-12-01

申请人： Taito Nishino ,  Katsuaki Miyaji ,  Shunsuke Iwamoto ,  Takumi Mikashima ,  Koichiro Saruhashi ,  Yo Kishikawa

发明人： Taito Nishino ,  Katsuaki Miyaji ,  Shunsuke Iwamoto ,  Takumi Mikashima ,  Koichiro Saruhashi ,  Yo Kishikawa

IPC分类号： C07D231/20

CPC分类号： C07D231/20 ,  C07D401/06 ,  C07D403/06

摘要： Novel therapeutic agents for myeloma are provided.A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): wherein R1 is C1-C6 alkyl, C1-C6 alkyl substituted with R17, C1-C6 haloalkyl, phenyl, phenyl substituted with a R11's or the like, R2 is a hydrogen atom, C1-C6 alkyl, phenyl or phenyl optionally substituted with e R21's or the like, R3 is a hydrogen atom or the like, X is a single bond or —(CR6, R7)n—, each of R4 and R5 is independently C1-C6 alkyl or the like, R6 and R7 are hydrogen atoms or C1-C6 alkyl, R8 is phenyl, phenyl optionally substituted with k R81's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient.

摘要翻译： 提供了新型骨髓瘤治疗剂。 一种含有由式（1）表示的吡唑化合物的多发性骨髓瘤治疗剂：其中R1是C1-C6烷基，被R17取代的C1-C6烷基，C1-C6卤代烷基，苯基，被R11等取代的苯基， R 2是氢原子，C 1 -C 6烷基，苯基或任选被e R 21等取代的苯基，R 3是氢原子等，X是单键或 - （CR 6，R 7）n - ，每个R 4 并且R 5独立地为C 1 -C 6烷基等，R 6和R 7为氢原子或C 1 -C 6烷基，R 8为苯基，任选被k R 81等取代的苯基，化合物的互变异构体或其药学上可接受的盐或溶剂合物 作为活性成分。

公开(公告)号：US08658686B2

公开(公告)日：2014-02-25

申请号：US13991024

申请日：2011-12-01

申请人： Taito Nishino ,  Katsuaki Miyaji ,  Shunsuke Iwamoto ,  Takumi Mikashima ,  Koichiro Saruhashi ,  Yo Kishikawa

发明人： Taito Nishino ,  Katsuaki Miyaji ,  Shunsuke Iwamoto ,  Takumi Mikashima ,  Koichiro Saruhashi ,  Yo Kishikawa

IPC分类号： A61K31/415 ,  C07D231/10

CPC分类号： C07D231/20 ,  C07D401/06 ,  C07D403/06

摘要： Novel therapeutic agents for myeloma are provided.A therapeutic agent for multiple myeloma containing a pyrazole compound represented by the formula (1): wherein R1 is C1-C6 alkyl, C1-C6 alkyl substituted with R17, C1-C6 haloalkyl, phenyl, phenyl substituted with a R11's or the like, R2 is a hydrogen atom, C1-C6 alkyl, phenyl or phenyl optionally substituted with e R21's or the like, R3 is a hydrogen atom or the like, X is a single bond or —(CR6R7)n—, each of R4 and R5 is independently C1-C6 alkyl or the like, R6 and R7 are hydrogen atoms or C1-C6 alkyl, R8 is phenyl, phenyl optionally substituted with k R81's or the like, a tautomer of the compound or a pharmaceutically acceptable salt or solvate thereof, as an active ingredient.

摘要翻译： 提供了新型骨髓瘤治疗剂。 一种含有由式（1）表示的吡唑化合物的多发性骨髓瘤治疗剂：其中R1是C1-C6烷基，被R17取代的C1-C6烷基，C1-C6卤代烷基，苯基，被R11等取代的苯基， R 2是氢原子，C 1 -C 6烷基，苯基或任选被e R 21等取代的苯基，R 3是氢原子等，X是单键或 - （CR 6 R 7）n - 各自为R 4和R 5 独立地为C 1 -C 6烷基等，R 6和R 7为氢原子或C 1 -C 6烷基，R 8为苯基，任选被k R 81等取代的苯基，化合物的互变异构体或其药学上可接受的盐或溶剂合物， 作为活性成分。