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公开(公告)号:US20060111334A1
公开(公告)日:2006-05-25
申请号:US11262952
申请日:2005-11-01
IPC分类号: A61K31/56
CPC分类号: A61K31/56 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2813 , A61K9/284 , A61K9/2866
摘要: The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.
摘要翻译: 本发明涉及含有非常低剂量的雌二醇的口服固体剂型。 剂型配制以避免雌二醇降解并使聚乙烯吡咯烷酮的含量最小化,同时仍然实现雌二醇的类似的快速溶解。 剂型可用于预防或治疗由内源性雌二醇不足引起的妇女的身体状况。
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公开(公告)号:US08022053B2
公开(公告)日:2011-09-20
申请号:US11262952
申请日:2005-11-01
IPC分类号: A61K31/56
CPC分类号: A61K31/56 , A61K9/2009 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2813 , A61K9/284 , A61K9/2866
摘要: The present invention relates to oral solid dosage forms containing a very low dose of estradiol. The dosage forms are formulated in a manner so as to avoid degradation of the estradiol and to minimise the content of polyvinylpyrrolidone, while still achieving similar fast dissolution of the estradiol. The dosage forms are useful in preventing or treating a physical condition in a woman caused by insufficient endogenous levels of estradiol.
摘要翻译: 本发明涉及含有非常低剂量的雌二醇的口服固体剂型。 剂型配制以避免雌二醇降解并使聚乙烯吡咯烷酮的含量最小化,同时仍然实现雌二醇的类似的快速溶解。 剂型可用于预防或治疗由内源性雌二醇不足引起的妇女的身体状况。
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