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1.发明授权Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors 失效基于计算机的模型，用于鉴定和表征烟碱乙酰胆碱受体和相关配体门控离子通道受体的非竞争性抑制剂公开(公告)号：US07749984B2
公开(公告)日：2010-07-06
申请号：US10820809
申请日：2004-04-09
IPC分类号： A61K314/85 , C07C69/88
摘要： A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
摘要翻译： 本发明提供了一种保存配体门控离子通道受体分子模型数据和/或用于建模所述受体的计算机系统的计算机可读介质。 该分子模型可用于设计具有作为离子通道的非竞争性抑制剂的活性的新型化合物。 本发明的优选实施方案涉及烟碱乙酰胆碱受体。 还公开了具有作为配体门控离子通道受体的非竞争性抑制剂的活性的化合物以及用于抑制受体和治疗由受体功能介导的疾病或病症的方法。
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2.发明申请Computer-based model for identification and characterization of non-competitive inhibitors of nicotinic acetylcholine receptors and related ligand-gated ion channel receptors 失效基于计算机的模型，用于鉴定和表征烟碱乙酰胆碱受体和相关配体门控离子通道受体的非竞争性抑制剂公开(公告)号：US20050033522A1
公开(公告)日：2005-02-10
申请号：US10820809
申请日：2004-04-09
IPC分类号： A61K31/00 , A61K31/43 , A61K38/00 , C07K1/00 , C07K14/705 , G06F19/00 , G01N33/48 , G01N33/50
摘要： A computer readable medium holding data of a molecular model of a ligand-gated ion channel receptor and/or a computer system for modeling said receptor are provided by the instant invention. The molecular model can be used to design novel compounds having activity as non-competitive inhibitors of the ion channel. A preferred embodiment of the invention relates to nicotinic acetylcholine receptors. Compounds having activity as non-competitive inhibitors of ligand-gated ion channel receptors and methods for inhibiting the receptor and treating diseases or disorders mediated by function of the receptor are also disclosed.
摘要翻译： 本发明提供了一种保存配体门控离子通道受体分子模型数据和/或用于建模所述受体的计算机系统的计算机可读介质。 该分子模型可用于设计具有作为离子通道的非竞争性抑制剂的活性的新型化合物。 本发明的优选实施方案涉及烟碱乙酰胆碱受体。 还公开了具有作为配体门控离子通道受体的非竞争性抑制剂的活性的化合物以及用于抑制受体和治疗由受体功能介导的疾病或病症的方法。
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