公开(公告)号：US20110038882A1

公开(公告)日：2011-02-17

申请号：US12855132

申请日：2010-08-12

Applicant: Bor-Luen Chiang ,  Chun-Jung Chang ,  Yu-Li Lin ,  Kuan-Hua Chu ,  Hong-Nong Chou ,  Jiunn-Ming Jeng

Inventor： Bor-Luen Chiang ,  Chun-Jung Chang ,  Yu-Li Lin ,  Kuan-Hua Chu ,  Hong-Nong Chou ,  Jiunn-Ming Jeng

IPC: A61K38/16 ,  A61P37/08 ,  A61P11/06 ,  A61P11/02 ,  A61P17/06 ,  A61P17/00 ,  A61P29/00 ,  A61P1/00 ,  A61P11/08 ,  A61P37/02

CPC classification number: A61K36/04 ,  A61K31/40

Abstract: A method for treating or alleviating allergic disease in a mammal in need thereof having administering to the mammal a therapeutically effective amount of a pharmaceutical composition having phycocyanin is provided. A method for modulating balance between Th1 and Th2 immune response in a mammal in need thereof, having administering to the mammal an effective amount of phycocyanin, wherein immune response of the mammal is skewed toward the Th1 immune response is also provided. Phycocyanin from Bangia atropupurea (Ba-PC) is identified to regulate mammalian immunological response indicating that Ba-PC can direct skewed immune response toward Th1 response through modulating DC function, increase proliferative activity of antigen-specific T cells and alleviate airway inflammation, confirming that phycobiliproteins are effective in treating allergic disease.

Abstract translation: 提供了一种治疗或缓解需要其的哺乳动物过敏性疾病的方法，该方法向哺乳动物施用治疗有效量的具有藻蓝蛋白的药物组合物。 还提供了一种用于调节有需要的哺乳动物中Th1和Th2免疫应答之间的平衡的方法，其给予哺乳动物有效量的藻蓝蛋白，其中哺乳动物的免疫应答偏向Th1免疫应答。 鉴定了来自Bangia atropupurea（Ba-PC）的藻蓝蛋白调节哺乳动物免疫应答，表明Ba-PC可通过调节DC功能，增加抗原特异性T细胞的增殖活性和减轻气道炎症来引导对Th1应答的偏斜免疫反应，证实 藻胆蛋白有效治疗过敏性疾病。