公开(公告)号：US20050014159A1

公开(公告)日：2005-01-20

申请号：US10618620

申请日：2003-07-15

申请人： Jui-Lin Chen ,  Yuchi Hwang ,  Min-Pey Ding ,  Wen-Pi Chu ,  Shu-Ching Wang ,  Kuei-Ling Chen ,  Wan-Lin Yao ,  Kuang-Den Chen ,  Ding-Shinn Chen ,  Pei-Jer Chen ,  Ming-Yang Lai

发明人： Jui-Lin Chen ,  Yuchi Hwang ,  Min-Pey Ding ,  Wen-Pi Chu ,  Shu-Ching Wang ,  Kuei-Ling Chen ,  Wan-Lin Yao ,  Kuang-Den Chen ,  Ding-Shinn Chen ,  Pei-Jer Chen ,  Ming-Yang Lai

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： It is provided isolated polynucleotides that include sequences from genomic region around the gene CD 81. The polynucleotides include polymorphisms associated with treatment response of HCV patients to interferon-α and ribavirin combined therapy and are useful as the probes in screening for patients who will response to interferon-α and ribavirin combined therapy. It is further provided linkage disequilibrium structure of the CD81 gene and haplotype information within a particular LD block, which can be used for prediction of the treatment outcome of the interferon-α and ribavirin combined therapy on HCV patients.

摘要翻译： 提供了分离的多核苷酸，其包括来自基因CD81周围的基因组区域的序列。多核苷酸包括与HCV患者对干扰素-α和利巴韦林联合治疗的治疗反应相关的多态性，并且可用作筛选将响应于 干扰素-α和利巴韦林组合治疗。 进一步提供CD81基因的连锁不平衡结构和特定LD区段内的单倍型信息，可用于预测干扰素-α和利巴韦林联合治疗对HCV患者的治疗结果。