公开(公告)号：US09163085B2

公开(公告)日：2015-10-20

申请号：US14240535

申请日：2012-02-09

申请人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

发明人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

IPC分类号： C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75

摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

摘要翻译： 公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。 优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。 抗体可以是全长抗体或其抗原结合部分。 抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。 提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

公开(公告)号：US20140308276A1

公开(公告)日：2014-10-16

申请号：US14240535

申请日：2012-02-09

申请人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

发明人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

IPC分类号： C07K16/28

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75

摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

摘要翻译： 公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。 优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。 抗体可以是全长抗体或其抗原结合部分。 抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。 提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

公开(公告)号：US09006399B2

公开(公告)日：2015-04-14

申请号：US13818645

申请日：2011-08-23

申请人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

发明人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75

摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.

摘要翻译： 公开了与人OX40特异性结合的人抗体，优选重组人抗体，人源化和嵌合。 优选的抗体对OX40受体具有高亲和力，并在体外和体内激活受体。 抗体可以是全长抗体或其抗原结合部分。 抗体或抗体部分可用于调节受体活性，例如在患有OX40活性有害的病症的人类受试者中。 提供用于表达重组人抗体的核酸，载体和宿主细胞，并提供合成重组人抗体的方法。

公开(公告)号：US20130280275A1

公开(公告)日：2013-10-24

申请号：US13818645

申请日：2011-08-23

申请人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

发明人： Yong-Jun Liu ,  Kui Shin Voo ,  Laura Bover ,  Naoya Tsurushita ,  J. Yun Tso ,  Shankar Kumar

IPC分类号： C07K16/28

CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/74 ,  C07K2317/75

摘要： Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human OX40 are disclosed. Preferred antibodies have high affinity for OX40 receptor and activate the receptor in vitro and in vivo. The antibody can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antibody portions, are useful for modulating receptor activity, e.g., in a human subject suffering from a disorder in which OX40 activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant human antibodies are provided, and methods of synthesizing the recombinant human antibodies, are also provided.