公开(公告)号：US20070185215A1

公开(公告)日：2007-08-09

申请号：US11401341

申请日：2006-04-10

申请人： Byoung-Mog Kwon ,  Kwang-Hee Son ,  Dong Han ,  Ji-Min Lee ,  Kyoungho Suk ,  Su Hong ,  Jiyeon Ock

发明人： Byoung-Mog Kwon ,  Kwang-Hee Son ,  Dong Han ,  Ji-Min Lee ,  Kyoungho Suk ,  Su Hong ,  Jiyeon Ock

IPC分类号： A61K31/075

CPC分类号： A61K31/075 ,  A61K36/57

摘要： Disclosed herein a pharmaceutical composition, comprising obovatol as an active ingredient, for the prevention and treatment of neurodegenerative diseases. Having superior inhibitory activity against the production of neurotoxic nitric oxides, the obovatol isolated and purified from Magnoliaceae can be used as active ingredient for a pharmaceutical composition or a neuroprotective agent for the prevention and treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.

摘要翻译： 本文公开了一种药物组合物，其包含用作预防和治疗神经退行性疾病的作为活性成分的高效醇。 对于神经毒性一氧化氮的生产具有优异的抑制活性，从木兰科分离和纯化的浮游动物可以用作药物组合物或神经保护剂的有效成分，用于预防和治疗神经变性疾病，例如阿尔茨海默病，帕金森氏病， 和多发性硬化症。

公开(公告)号：US20140057267A1

公开(公告)日：2014-02-27

申请号：US14112836

申请日：2012-04-02

申请人： Kyoungho Suk ,  Ho Won Lee ,  Ji Hye Choi

发明人： Kyoungho Suk ,  Ho Won Lee ,  Ji Hye Choi

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  C12Q1/6883 ,  C12Q2600/158

摘要： The present invention relates to a composition for the diagnosis of mild cognitive impairment, which includes a formulation measuring an mRNA or protein expression level of lipocalin-2 gene, to a kit for the diagnosis of mild cognitive impairment, and to a method for providing information for the diagnosis of mild cognitive impairment using the same. According to the present invention, by using the agent for measuring an mRNA or protein expression level of the lipocalin-2 gene, a patient having mild cognitive impairment can be specifically identified by measuring an expression level of lipocalin-2, which is higher in a group of patients having mild cognitive impairment than in both a normal group and a group of patients having Alzheimer's disease.; In particular, it is possible to distinguish between a group of patients having mild cognitive impairment and a group of patients having Alzheimer's disease

摘要翻译： 本发明涉及用于诊断轻度认知障碍的组合物，其包括测量脂质运载蛋白-2基因的mRNA或蛋白质表达水平的制剂，用于诊断轻度认知障碍的试剂盒，以及用于提供信息的方法 用于轻度认知功能障碍的诊断。 根据本发明，通过使用用于测定脂质运载蛋白-2基因的mRNA或蛋白质表达水平的试剂，可以通过测定脂质运载蛋白-2的表达水平来特异性鉴定具有轻度认知障碍的患者， 具有轻度认知障碍的患者组比正常组和一组患有阿尔茨海默病的患者组; 特别地，可以区分一组具有轻度认知障碍的患者和一组患有阿尔茨海默氏病的患者