公开(公告)号：US20090048247A1

公开(公告)日：2009-02-19

申请号：US11815695

申请日：2006-02-13

申请人： Venkata P. Palle ,  Sarala Balachandran ,  Nidhi Gupta ,  Nagarajan Muthukamal ,  Mandadapu Raghu Ramaiah ,  Manoj Kumar Khera ,  Lailt Kumar Baregama ,  Vinayak Vasantrao Khairnar ,  Abhijit Ray ,  Sunanda G. Dastidar

发明人： Venkata P. Palle ,  Sarala Balachandran ,  Nidhi Gupta ,  Nagarajan Muthukamal ,  Mandadapu Raghu Ramaiah ,  Manoj Kumar Khera ,  Lailt Kumar Baregama ,  Vinayak Vasantrao Khairnar ,  Abhijit Ray ,  Sunanda G. Dastidar

IPC分类号： A61K31/5377 ,  C07D498/10 ,  A61K31/424 ,  A61P31/18

CPC分类号： C07D261/20

摘要： The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

摘要翻译： 本发明涉及异恶唑啉衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 特别地，本文公开的化合物可用于治疗AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是在人类中。 本发明还涉及制备所公开的化合物及其药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途的方法。