公开(公告)号：US20050222185A1

公开(公告)日：2005-10-06

申请号：US11095686

申请日：2005-04-01

申请人： Chang Ahn ,  Won Choi ,  Young Lee ,  Lak Jeong ,  Sang Lee

发明人： Chang Ahn ,  Won Choi ,  Young Lee ,  Lak Jeong ,  Sang Lee

IPC分类号： A61K31/513 ,  C07D239/46 ,  C07D239/54 ,  C07D239/553

CPC分类号： C07D239/47 ,  A61K31/513 ,  C07D239/54 ,  C07D239/553

摘要： The present invention relates to nucleoside derivatives represented by general formulas I and II, their synthetic methods and their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

摘要翻译： 本发明涉及由通式I和II表示的核苷衍生物，其合成方法及其药理学上可接受的盐，以及含有这些化合物的组合物。 还包括通过施用化合物治疗过度增殖性疾病的方法。

公开(公告)号：US20050256143A1

公开(公告)日：2005-11-17

申请号：US10530552

申请日：2003-10-24

申请人： Lak Jeong ,  Kenneth Jacobson ,  Hyung Moon ,  Hea Kim

发明人： Lak Jeong ,  Kenneth Jacobson ,  Hyung Moon ,  Hea Kim

IPC分类号： A61K31/52 ,  A61K31/7076 ,  A61P29/00 ,  A61P35/00 ,  C07D473/00 ,  C07D473/14 ,  C07D473/32 ,  C07D473/34 ,  C07H19/16 ,  C07H19/167

CPC分类号： C07H5/10 ,  C07D473/00 ,  C07D473/32 ,  C07D473/34 ,  C07H19/16 ,  C07H19/167

摘要： Disclosed are purine nucleoside compounds that are selective to A3 adenosine receptors and are useful for the treatment of cancer and inflammatory diseases. The compounds are shown by the following general formula (I), including isomers thereof: wherein X is sulfur or oxygen; R1 is hydrogen, alkyl, benzyl, halobenzyl, or phenylalkyl; R2 is hydrogen, halogen, alkoxy, alkenyl, alkynyl, alkylthio, or thio; R3 and R3′ are hydrogen, hydroxyalkyl, alkoxycarbonyl, or alkylaminocabonyl, whereas R3 and R3′ do not have identical substituents simultaneously; and R4 is hydrogen or alkyl. Also disclosed are a pharmaceutical composition comprising a compound of formula (I), an isomer, or its pharmacologically acceptable salt as an active ingredient and a method for preventing or treating various diseases, state, or condition, including asthma, inflammation, cerebral ischemia, heart diseases, and cancer.

摘要翻译： 公开了对Aβ3 +腺苷受体有选择性的嘌呤核苷化合物，可用于治疗癌症和炎性疾病。 所述化合物由以下通式（I）表示，包括其异构体：其中X为硫或氧; R 1是氢，烷基，苄基，卤代苄基或苯基烷基; R 2是氢，卤素，烷氧基，烯基，炔基，烷硫基或硫代; R 3和R 3'是氢，羟基烷基，烷氧基羰基或烷基氨基羰基，而R 3和R 3' “同时没有相同的取代基; 并且R 4是氢或烷基。 还公开了包含式（I）化合物，异构体或其药理学上可接受的盐作为活性成分的药物组合物和预防或治疗各种疾病，状态或病症的方法，包括哮喘，炎症，脑缺血， 心脏病和癌症。