公开(公告)号：US20050101826A1

公开(公告)日：2005-05-12

申请号：US10712820

申请日：2003-11-12

申请人： Lane Bray ,  David Swanberg ,  James Madsen ,  Jay Draper ,  Garrett Brown ,  Matthew Bales ,  Donald Lawrence ,  Karen Thompson

发明人： Lane Bray ,  David Swanberg ,  James Madsen ,  Jay Draper ,  Garrett Brown ,  Matthew Bales ,  Donald Lawrence ,  Karen Thompson

IPC分类号： A61L31/16 ,  A61N5/10 ,  A61M36/12 ,  C04B33/32

CPC分类号： A61L31/18 ,  A61N5/1001 ,  A61N2005/1024

摘要： This invention includes methods of fabricating brachytherapy implant seeds, methods of fabricating brachytherapy implant seed cores, and brachytherapy implant seeds independent of method of fabrication. In one implementation, a brachytherapy implant seed includes a sealed inorganic metallic cylinder having a radioactive core received therein. The radioactive core includes an inorganic amorphous silicate glass tube having an exterior surface extending axially along the tube. An inorganic crystalline ceramic coating is received on at least a portion of the inorganic amorphous glass tube exterior surface. The coating includes a therapeutic dose of radioactive material. A radiographic marker is received within the sealed inorganic metallic cylinder. Other aspects and implementations are contemplated.

摘要翻译： 本发明包括制造近距离放射治疗种植种子的方法，制造近距离放射植入物种子芯的方法以及与制造方法无关的近距离放射植入种子。 在一个实施方案中，近距离放射线植入种子包括其中容纳有放射性核的密封的无机金属圆筒。 放射性核心包括具有沿着管轴向延伸的外表面的无机无定形硅酸盐玻璃管。 在无机非晶玻璃管外表面的至少一部分上接收无机结晶陶瓷涂层。 涂层包括治疗剂量的放射性物质。 在密封的无机金属圆筒内容纳射线照相标记物。 考虑了其他方面和实现。

公开(公告)号：US20060051269A1

公开(公告)日：2006-03-09

申请号：US11158899

申请日：2005-06-22

申请人： Lane Bray ,  Garrett Brown

发明人： Lane Bray ,  Garrett Brown

IPC分类号： C01F5/00

CPC分类号： G21G4/08 ,  G21G1/06 ,  G21G4/00

摘要： The present invention provides a method of separating and purifying Cesium-131 (Cs-131) from Barium (Ba). Uses of the Cs-131 purified by the method include cancer research and treatment, such as for the use in brachytherapy. Cs-131 is particularly useful in the treatment of faster growing tumors.

摘要翻译： 本发明提供了从钡（Ba）中分离和纯化铯-131（Cs-131）的方法。 通过该方法纯化的Cs-131的使用包括癌症研究和治疗，如用于近距离放射治疗。 Cs-131在治疗生长较快的肿瘤中特别有用。

公开(公告)号：US20060024223A1

公开(公告)日：2006-02-02

申请号：US11191143

申请日：2005-07-27

申请人： Lane Bray ,  Garrett Brown ,  David Swanberg

发明人： Lane Bray ,  Garrett Brown ,  David Swanberg

IPC分类号： C22B3/00

CPC分类号： G21G4/08 ,  C22B3/165 ,  C22B3/44 ,  C22B26/00 ,  G21G1/06 ,  Y02P10/234

摘要： The present invention provides a method of separating and purifying Cesium-131 (Cs-131) from Barium (Ba). Uses of the Cs-131 purified by the method include cancer research and treatment, such as for the use in brachytherapy. Cs-131 is particularly useful in the treatment of faster growing tumors.

公开(公告)号：US20060167332A1

公开(公告)日：2006-07-27

申请号：US11198873

申请日：2005-08-05

申请人： Lane Bray

发明人： Lane Bray

IPC分类号： A61N5/00 ,  A61K51/00

CPC分类号： G21G4/08 ,  A61K51/1255 ,  A61K51/1268 ,  A61N2005/1019 ,  B82Y5/00

摘要： The present invention provides a method of preparing Cesium-131 (Cs-131) as a dispersed radioisotope. Uses of the dispersed Cs-131 prepared by the method include cancer research and treatment, such as for the use in brachytherapy. Cs-131 is particularly useful in the treatment of faster growing tumors.

摘要翻译： 本发明提供了制备作为分散的放射性同位素的铯-131（Cs-131）的方法。 通过该方法制备的分散Cs-131的使用包括癌症研究和治疗，如用于近距离放射治疗。 Cs-131在治疗生长较快的肿瘤中特别有用。

公开(公告)号：US20060018813A1

公开(公告)日：2006-01-26

申请号：US11189131

申请日：2005-07-25

申请人： Lane Bray

发明人： Lane Bray

IPC分类号： C22B60/00

CPC分类号： G21F9/08 ,  C01F11/36 ,  C01F17/0075 ,  C01P2006/88 ,  C22B3/065 ,  C22B3/44 ,  C22B26/20 ,  C22B59/00 ,  G21G4/08 ,  Y02P10/234

摘要： The present invention provides a method of separating and purifying Yttrium-90 (Y-90) from Strontium-90 (Sr-90). In addition, a zirconium (Zr) clean-up step for the Y-90 is provided. Uses of the Y-90 purified by the method include cancer research and treatment. Y-90 is particularly useful in cell directed therapy, e.g., where the Y-90 is attached directly or indirectly to a targeting molecule such as an antibody.