公开(公告)号：US20120021077A1

公开(公告)日：2012-01-26

申请号：US12669643

申请日：2008-07-18

申请人： Bhushan Patwardhan ,  Arvind Chopra ,  Gumdal Narsimulu ,  Rohini Handa ,  Lata S. Bichile ,  Ghulam Nabi Qazi ,  Arvind Manohar Mujumdar ,  Venil N. Sumantran ,  Palpu Pushpangadam ,  Shanta Mehrotra ,  Ajay Kumar Singh Rawat ,  Sayyada Khatoon ,  Subha Rastogi ,  Govindarajan Raghavan ,  Ashwinikumar Raut

发明人： Bhushan Patwardhan ,  Arvind Chopra ,  Gumdal Narsimulu ,  Rohini Handa ,  Lata S. Bichile ,  Ghulam Nabi Qazi ,  Arvind Manohar Mujumdar ,  Venil N. Sumantran ,  Palpu Pushpangadam ,  Shanta Mehrotra ,  Ajay Kumar Singh Rawat ,  Sayyada Khatoon ,  Subha Rastogi ,  Govindarajan Raghavan ,  Ashwinikumar Raut

IPC分类号： A61K36/9068 ,  A61P21/00 ,  A61P19/00 ,  A61P39/06 ,  A61K36/81 ,  A61P29/00

CPC分类号： A61K36/185 ,  A61K36/324 ,  A61K36/47 ,  A61K36/59 ,  A61K36/81 ,  A61K36/9068 ,  A61K2300/00

摘要： The present invention deals with a synergistic herbal composition useful for treatment of rheumatic and musculo-skeletal disorders (RMSDs) comprising a base formulation (50-60%) and plant parts and/or extracts of the plant (40-50%) selected from the group consisting of Withania somnifera, Tribulus terrestris, Phyllanthus emblica and Boswellia serrata optionally along with pharmaceutically acceptable excipients. The herbal formulation is capable of causing simultaneous long term decrease in glycosaminoglycan (GAG) release and aggrecan by cartilage explants resulting in reduction of pain, inflammation, stiffness and low degeneration of bones, joints, muscles and other connective tissues. The present invention further deals with a process for the preparation of the said herbal formulation and a method of treating RMSDs using the formulation up to a high safety level and stable for a long durations.

摘要翻译： 本发明涉及用于治疗风湿性和肌肉 - 骨骼疾病（RMSDs）的协同草药组合物，其包含基础制剂（50-60％）和植物部分和/或植物提取物（40-50％），选自 该组包括有睡莲，Trib藜，竹a和芥子草，任选地与药学上可接受的赋形剂。 草药制剂能够通过软骨外植体同时长期降低糖胺聚糖（GAG）释放和聚集蛋白聚糖，导致骨骼，关节，肌肉和其他结缔组织的疼痛，炎症，僵硬和变性降低。 本发明进一步涉及制备所述草药制剂的方法和使用该制剂治疗RMSD的方法，该方法达到高安全性水平并且在长时间内稳定。