公开(公告)号：US20070092878A1

公开(公告)日：2007-04-26

申请号：US10550608

申请日：2004-03-25

申请人： Antonio Martinez ,  Laureano Buela ,  Simon Cruz ,  Maria Jimenez ,  Corina Sanchez-Vallejo ,  Jose Roman ,  Jorge Gonzalez ,  Miguel Vila

发明人： Antonio Martinez ,  Laureano Buela ,  Simon Cruz ,  Maria Jimenez ,  Corina Sanchez-Vallejo ,  Jose Roman ,  Jorge Gonzalez ,  Miguel Vila

IPC分类号： C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC分类号： G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2333/71

摘要： The present invention refers to an in vitro method to detect a bladder transitional cell carcinoma, in an individual, to determine the stage or severity of this cancer in an individual or to monitor the effect of therapy administered to an individual with this cancer; to screen for, identify, develop and evaluate the efficacy of therapeutic compounds against this cancer in order to develop new medicinal products, and also agents that inhibit the expression and/or activity of the FGFR3 protein and/or the effects of this expression.

摘要翻译： 本发明涉及在个体中检测膀胱移行细胞癌的体外方法，以确定个体中该癌症的阶段或严重程度或监测对患有该癌症的个体施用的治疗效果; 筛选，鉴定，开发和评价治疗性化合物对该癌症的功效以开发新的药物产品，以及抑制FGFR3蛋白的表达和/或活性和/或该表达的作用的试剂。