Pharmaceutical tablet suitable to deliver the active substance in subsequent and predeterminable times
    2.
    发明授权
    Pharmaceutical tablet suitable to deliver the active substance in subsequent and predeterminable times 失效
    适于在随后和可预定的时间内递送活性物质的药物片剂

    公开(公告)号:US06294200B1

    公开(公告)日:2001-09-25

    申请号:US08795382

    申请日:1997-02-04

    IPC分类号: A61K924

    CPC分类号: A61K9/209 A61K9/2072

    摘要: Pharmaceutical tablet, capable of delivering the active substance or the active substances, according to a predeterminable release profile, comprising a core with an external partial coating in which said core consists of 3 layers, wherein the upper layer contains an amount of the active substance with suitable excipients, the intermediate layer consists of polymeric material with retarding barrier function and the lower layer contains the remaining amount of the active substance with suitable excipients and said external coating consists of controlled permeability polymeric materials, applied by compression to the lower surface and to the lateral surface of the core.

    摘要翻译: 能够根据可预先确定的释放曲线递送活性物质或活性物质的药片,其包含具有外部部分涂层的芯,其中所述芯由3层组成,其中上层含有一定量的活性物质, 合适的赋形剂,中间层由具有阻滞阻隔功能的聚合物材料组成,下层包含剩余量的具有合适赋形剂的活性物质,所述外部涂层由受控的渗透性聚合材料组成,通过压缩施加到下表面 芯的侧面。

    Pharmaceutical tablet characterized by a showing high volume increase
when coming into contact with biological fluids
    3.
    发明授权
    Pharmaceutical tablet characterized by a showing high volume increase when coming into contact with biological fluids 失效
    药片,其特征在于当与生物流体接触时显示出高体积增加

    公开(公告)号:US5780057A

    公开(公告)日:1998-07-14

    申请号:US799313

    申请日:1997-02-14

    IPC分类号: A61K47/00 A61K9/20 A61K9/28

    CPC分类号: A61K9/2086

    摘要: A description is given of a pharmaceutical form for oral administration consisting of a two- or three-layers tablet, wherein at least one layer can rapidly swell by contact with biological and/or aqueous fluids, said swelling resulting in a considerable increase in the tablet volume. Said phenomenon determines a prolonged residence of the pharmaceutical form at the gastric level and therefore allows a slow release of the active ingredient from said pharmaceutical form to the stomach and/or the first tract of the intestine.

    摘要翻译: 给出了用于口服给药的药物形式的描述,其由两层或三层片剂组成,其中至少一层可通过与生物和/或含水流体的接触而迅速溶胀,所述溶胀导致片剂显着增加 卷。 所述现象确定药物形式在胃水平上的延长的停留,因此允许活性成分从所述药物形式缓慢释放到胃和/或肠的第一道。

    Therapeutic system for the controlled release of active ingredients
    5.
    发明申请
    Therapeutic system for the controlled release of active ingredients 审中-公开
    用于控释活性成分的治疗系统

    公开(公告)号:US20050095295A1

    公开(公告)日:2005-05-05

    申请号:US10507344

    申请日:2003-03-12

    摘要: A system designed to release one or more active substances in different, previously programmable modes, is described. The system is constituted by a tablet in three layers, two of which (the outer layers) vehicularise the active ingredient(s), whilst the third (the central layer) is constituted of a polymeric barrier which does not contain active substance and has the appropriate characteristics of erodibility or gelation. The tablet is completely coated with a film of polymeric material insoluble in water and/or in aqueous fluids, on which one or more incisions delimiting an area of exactly calculated geometric shape and size, have been made through the use of a laser beam of appropriate power and intensity. The removal of the film inside the incision(s) allows the release of the active ingredient(s) into aqueous fluid in predetermined amounts and umes. The procedure for the production of the aforementioned pharmaceutical form is also described.

    摘要翻译: 描述了设计用于释放不同的先前可编程模式中的一种或多种活性物质的系统。 该系统由三层的片剂构成,其中两层(外层)是活性成分,而第三层(中心层)由不含活性物质的聚合物屏障构成,并具有 适当的可蚀性或凝胶化特性。 片剂完全涂覆有不溶于水和/或水性流体的聚合物材料薄膜,其中通过使用适当的激光束制成限定精确计算的几何形状和尺寸的区域的一个或多个切口 功率和强度。 在切口内去除膜允许活性成分以预定量和ume释放到水性流体中。 还描述了用于生产上述药物形式的方法。

    Controlled release pharmaceutical tablets containing an active principle of low water solubility
    6.
    发明授权
    Controlled release pharmaceutical tablets containing an active principle of low water solubility 有权
    含有低水溶性活性成分的控释药片

    公开(公告)号:US06221395B1

    公开(公告)日:2001-04-24

    申请号:US09144711

    申请日:1998-09-01

    IPC分类号: A61K920

    CPC分类号: A61K9/0004 A61K31/4422

    摘要: It is described a new method for the preparation of pharmaceutical tablets carrying poorly soluble in water principle; this method allows to obtain tablets with fast and/or slow release of the active principle. The peculiar feature is the fact that the poorly soluble in water active principle (es: nifedipine) is treated with a surfactant, during the granulation phase or whatever during the preparation process; the obtained product, subjected to a compression, produces pharmaceutical tablets which show high bioavailability of the carried active principle. This procedure can be used to prepare polymeric matrixes (with modified release), formed by tablets with one or more layers. The procedure of manufacture and the characteristics of the new finished tablet are described.

    摘要翻译: 描述了一种用于制备溶于水的原料的药物片剂的新方法; 该方法允许获得具有快速和/或缓慢释放活性成分的片剂。 特殊的特征是,在制粒阶段期间或在制备过程中任何时候,用表面活性剂处理难溶于水的活性成分(es:硝苯地平) 所获得的产品经受压缩后,产生显示生物利用率高的药物片剂。 该方法可用于制备具有一层或多层的片剂形成的聚合物基质(具有改性释放)。 描述了制造过程和新成品片的特点。

    Multilayered controlled-release oral solid pharmaceutical forms
    7.
    发明授权
    Multilayered controlled-release oral solid pharmaceutical forms 失效
    多层控释口服固体药物形式

    公开(公告)号:US5681583A

    公开(公告)日:1997-10-28

    申请号:US397187

    申请日:1995-04-25

    IPC分类号: A61K9/24

    CPC分类号: A61K9/209

    摘要: Multilayered controlled-release solid pharmaceutical composition in tablet form suitable for oral administration comprising at least two layers containing active material in association with excipients and additives. One layer of the tablet releases a portion of the drug quickly while the other layer and optionally further layers release portions of the drug more gradually.

    摘要翻译: PCT No.PCT / EP94 / 01050 Sec。 371日期1995年04月25日 102(e)1995年4月25日PCT PCT 1994年4月2日PCT公布。 公开号WO95 / 01781 日期1995年1月19日多片适用于口服给药的片剂形式的控释固体药物组合物,其包含与赋形剂和添加剂相关的包含活性物质的至少两层。 片剂的一层快速释放药物的一部分,而另一层和任选的其它层更逐渐地释放药物的部分。