公开(公告)号：US20160272597A1

公开(公告)日：2016-09-22

申请号：US15034878

申请日：2014-07-28

申请人： LEE PHARMA LIMITED

发明人： Raghu Mitra Alla ,  Ajay Kumar Dubey ,  Srinivas Reddy Mallepalli ,  Ramakrishna Reddy Pongilati

IPC分类号： C07D263/20

CPC分类号： C07D263/20 ,  A61K31/5377 ,  C07B2200/07 ,  Y02A50/473 ,  Y02A50/481 ,  Y02A50/483

摘要： The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)—N-[[3-[4-fluoro-3-morpholino phenyl]-2-oxooxazolidin-5-yl] methyl] acetamide] compound of Formula-I which was disclosed in Indian Patent Application No. 5063/CHE/2013 and corresponding PCT/IN2014/000018. The compound is a broad spectrum antimicrobial agent effective against Multi-Drug Resistant S. Maltophilia pathogen and a large number of gram positive and gram negative pathogens. The compound has shown excellent biological activities against S. Maltophilia which has developed resistance against a large number of antibiotics including some of the known and widely used oxazolidinone derivatives.

公开(公告)号：US20180265513A1

公开(公告)日：2018-09-20

申请号：US15542093

申请日：2015-02-20

申请人： Lee Pharma Limited

发明人： Venkat Reddy Alla ,  Raghumitra Alla ,  Srinivas Reddy Mallepalli ,  Suresh Babu Nandam ,  Madhukar Reddy Guda ,  Raja Reddy Alluri

IPC分类号： C07D487/04 ,  C07C233/05

CPC分类号： C07D487/04 ,  C07B2200/07 ,  C07B2200/13 ,  C07C233/05

摘要： The present invention relates to a novel and improved process for the preparation of Sitagliptin of Formula (I) and its pharmaceutically acceptable salts. The present invention also relates to novel intermediates and process for the preparation of intermediates used in the preparation of Sitagliptin.

公开(公告)号：US09573910B2

公开(公告)日：2017-02-21

申请号：US15034878

申请日：2014-07-28

申请人： Lee Pharma Limited

发明人： Raghu Mitra Alla ,  Ajay Kumar Dubey ,  Srinivas Reddy Mallepalli ,  Ramakrishna Reddy Pongilati

IPC分类号： C07D263/20 ,  A61K31/5377

CPC分类号： C07D263/20 ,  A61K31/5377 ,  C07B2200/07 ,  Y02A50/473 ,  Y02A50/481 ,  Y02A50/483

摘要： The invention relates to novel oxazolidinone compound. More particularly, the invention relates to novel [(S)—N-[[3-[4-fluoro-3-morpholino phenyl]-2-oxooxazolidin-5-yl] methyl] acetamide] compound of Formula-I which was disclosed in Indian Patent Application No. 5063/CHE/2013 and corresponding PCT/IN2014/000018. The compound is a broad spectrum antimicrobial agent effective against Multi-Drug Resistant S. Maltophilia pathogen and a large number of gram positive and gram negative pathogens. The compound has shown excellent biological activities against S. Maltophilia which has developed resistance against a large number of antibiotics including some of the known and widely used oxazolidinone derivatives.

摘要翻译： 本发明涉及新型恶唑烷酮化合物。 更具体地，本发明涉及式I的新的[（S）-N - [[3- [4-氟-3-吗啉代苯基] -2-氧代恶唑烷-5-基]甲基]乙酰胺]化合物 在印度专利申请No.5063 / CHE / 2013和相应的PCT / IN2014 / 000018中。 该化合物是一种广泛的抗菌药物，可有效抵抗多药耐药性马氏杆菌病原体和大量革兰氏阳性和革兰氏阴性病原体。 该化合物已经显示出对马耳他菌的优良生物活性，其对大量抗生素产生抗性，包括一些已知且广泛使用的恶唑烷酮衍生物。

公开(公告)号：US10450315B2

公开(公告)日：2019-10-22

申请号：US15542093

申请日：2015-02-20

申请人： Lee Pharma Limited ,  Venkat Reddy Alla ,  Raghumitra Alla ,  Srinivas Reddy Mallepalli ,  Suresh Babu Nandam ,  Madhukar Reddy Guda ,  Raja Reddy Alluri

发明人： Venkat Reddy Alla ,  Raghumitra Alla ,  Srinivas Reddy Mallepalli ,  Suresh Babu Nandam ,  Madhukar Reddy Guda ,  Raja Reddy Alluri

IPC分类号： C07D487/04 ,  C07C233/05

摘要： The present invention relates to a novel and improved process for the preparation of Sitagliptin of Formula (I) and its pharmaceutically acceptable salts. The present invention also relates to novel intermediates and process for the preparation of intermediates used in the preparation of Sitagliptin.