公开(公告)号：US07805396B2

公开(公告)日：2010-09-28

申请号：US10448379

申请日：2003-05-30

申请人： Peter Wagner ,  Lene Martin

发明人： Peter Wagner ,  Lene Martin

IPC分类号： G06F9/44 ,  G06F15/18 ,  G06N7/02 ,  G06N7/06 ,  G06G7/00

CPC分类号： G01N33/743 ,  G06F19/00 ,  G16H10/40

摘要： Normal and abnormal diurnal cortisol secretion patterns are identified from human saliva samples by an in vitro method. First and second saliva samples are taken from one human individual at first and second predetermined times during the same day. A first cortisol concentration is determined in the first saliva sample, and a second cortisol concentration is determined in the second saliva sample. An abnormal secretion pattern is then compared to a normal secretion pattern with the help of a fuzzy logic algorithm. A function of the hypothalamic-pituitary-adrenal (HPA) axis is then determined for the human individual. Optionally, a testosterone level is determined from one of the samples and is used in combination with the cortisol concentrations to provide a redefined determination.

摘要翻译： 通过体外方法从人唾液样品鉴定正常和异常昼夜皮质醇分泌模式。 在同一天的第一和第二预定时间，从一个人的个体中取出第一和第二个唾液样品。 在第一唾液样品中测定第一皮质醇浓度，并且在第二唾液样品中测定第二皮质醇浓度。 借助于模糊逻辑算法，将异常分泌模式与正常分泌模式进行比较。 然后为人类确定下丘脑 - 垂体 - 肾上腺（HPA）轴的功能。 任选地，从一个样品确定睾酮水平，并与皮质醇浓度组合使用以提供重新定义的测定。

公开(公告)号：US20100241606A9

公开(公告)日：2010-09-23

申请号：US10448379

申请日：2003-05-30

申请人： Peter Wanger ,  Lene Martin

发明人： Peter Wanger ,  Lene Martin

IPC分类号： G06F9/44

CPC分类号： G01N33/743 ,  G06F19/00 ,  G16H10/40

摘要： Normal and abnormal diurnal cortisol secretion patterns are identified from human saliva samples by an in vitro method. First and second saliva samples are taken from one human individual at first and second predetermined times during the same day. A first cortisol concentration is determined in the first saliva sample, and a second cortisol concentration is determined in the second saliva sample. An abnormal secretion pattern is then compared to a normal secretion pattern with the help of a fuzzy logic algorithm. A function of the hypothalamic-pituitary-adrenal (HPA) axis is then determined for the human individual. Optionally, a testosterone level is determined from one of the samples and is used in combination with the cortisol concentrations to provide a redefined determination.

摘要翻译： 通过体外方法从人唾液样品鉴定正常和异常昼夜皮质醇分泌模式。 在同一天的第一和第二预定时间，从一个人的个体中取出第一和第二个唾液样品。 在第一唾液样品中测定第一皮质醇浓度，并且在第二唾液样品中测定第二皮质醇浓度。 借助于模糊逻辑算法，将异常分泌模式与正常分泌模式进行比较。 然后为人类确定下丘脑 - 垂体 - 肾上腺（HPA）轴的功能。 任选地，从一个样品确定睾酮水平，并与皮质醇浓度组合使用以提供重新定义的测定。