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公开(公告)号:US20060165705A1
公开(公告)日:2006-07-27
申请号:US10198003
申请日:2002-07-17
申请人: Leo Chalupa , Emine Gunhan , Prabhakara Choudary
发明人: Leo Chalupa , Emine Gunhan , Prabhakara Choudary
IPC分类号: A61K39/395 , C07K16/46
CPC分类号: C07K16/18 , A61K47/6825 , A61K47/6843 , A61K47/6849 , C07K16/28
摘要: The present invention provides immunoselective targeting agents that bind to transporters that are transiently accessible on the surface of neuronal cells, and that deliver compounds selectively to such cells. The invention provides methods of selectively killing, as well as methods of selectively promoting survival of, a neuronal cell.
摘要翻译: 本发明提供了与神经元细胞表面上瞬时可及的转运蛋白结合的免疫选择性靶向剂,并且将化合物选择性地递送至这些细胞。 本发明提供选择性杀伤的方法以及选择性促进神经元细胞存活的方法。