公开(公告)号：US20070225343A1

公开(公告)日：2007-09-27

申请号：US11680893

申请日：2007-03-01

申请人： Ramesh Krishnamoorthy ,  Leo Trevino ,  Richard Evans

发明人： Ramesh Krishnamoorthy ,  Leo Trevino ,  Richard Evans

IPC分类号： A61K31/427

CPC分类号： A61K31/427 ,  A61K9/0048 ,  A61K9/08 ,  A61K47/10 ,  A61K47/26 ,  A61K47/34

摘要： The present invention relates to an aqueous pharmaceutical formulation comprising at least one latrunculin and the formulation does not contain a substantial amount of dimethyl sulfoxide. In one embodiment, the present invention is directed to an aqueous pharmaceutical formulation comprising at least one latrunculin in an amount of 0.001-2% w/v, a non-ionic surfactant in an amount of 0.01-2% w/v, and a tonicity agent to maintain a tonicity between 200-400 mOsm/kG, at a pH between 4 to 8, wherein the latrunculin, the surfactant, and the tonicity agent are compatible in the formulation, and the formulation does not contain a substantial amount of dimethyl sulfoxide. The formulation is stable for at least six month at refrigerated temperature. The present invention further provides a method of reducing intraocular pressure, a method of treating glaucoma, a method of inhibiting wound healing after trabeculectomy, and a method of inhibiting angiogenesis.

摘要翻译： 本发明涉及含有至少一种梭菌素的水性药物制剂，并且所述制剂不含有大量的二甲基亚砜。 在一个实施方案中，本发明涉及包含0.001-2％w / v的量的至少一种latrunculin的水性药物制剂，0.01-2％w / v的量的非离子表面活性剂，和 张力剂以保持200-400mOsm / kG之间的张力，在4至8之间的pH下，其中所述莱特乐宁，表面活性剂和张力剂在制剂中相容，并且制剂中不含有大量的二甲基 亚砜。 该制剂在冷藏温度下稳定至少6个月。 本发明还提供降低眼内压的方法，治疗青光眼的方法，小梁切除术后抑制伤口愈合的方法以及抑制血管发生的方法。