Isoforms of mouse serotonin 5-HT2c receptor
    2.
    发明授权
    Isoforms of mouse serotonin 5-HT2c receptor 失效
    小鼠5-羟色胺5-HT2c受体的同种型

    公开(公告)号:US06835548B2

    公开(公告)日:2004-12-28

    申请号:US10280858

    申请日:2002-12-17

    IPC分类号: G01N33567

    摘要: The invention includes mouse serotonin 5-HT2c receptor isoforms having amino acid replacements at one or more positions of the natural mouse serotonin 5-HT2c receptor polypeptide sequence, specifically at one or more of positions 157, 159 and 161. The polypeptides are useful for identifying ligands which bind with the serotonin 5-HT2c receptor and modulators of the serotonin 5-HT2c, and for identifying drugs with affinity for 5-HT2 receptors which are used to treat schizophrenia, Parkinsonism, and anxiety disorders.

    摘要翻译: 本发明包括在天然小鼠5-羟色胺5-HT 2C受体多肽序列的一个或多个位置具有氨基酸取代的小鼠5-羟色胺5-HT2c受体亚型,特别是位置157,159和161中的一个或多个。多肽可用于鉴定 与血清素5-HT2c受体结合的配体和5-羟色胺5-HT2c的调节剂,并用于鉴定用于治疗精神分裂症,帕金森综合征和焦虑症的5-HT2受体的亲和力的药物。