公开(公告)号：US20120245048A1

公开(公告)日：2012-09-27

申请号：US13429143

申请日：2012-03-23

申请人： Jennifer Joy SMITH ,  John David AITCHISON ,  Leslie Rae MILLER

发明人： Jennifer Joy SMITH ,  John David AITCHISON ,  Leslie Rae MILLER

IPC分类号： C40B30/04 ,  C12Q1/02

CPC分类号： G01N33/5091 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2835

摘要： The invention provides a method to detect an abnormal condition or disease state by assessing a characteristic response pattern of responder cells to indicators contained in a biological fluid of a subject. A characteristic disease-associated pattern can be obtained by determining the response pattern of responder cells to that of bodily fluids or fractions thereof from subjects known to exhibit a particular abnormal condition optionally comparing said pattern to such pattern elicited by fluids or fractions from normal subjects and identifying elements that differ. The identified elements constitute a characteristic or differential pattern which can then be used to identify the presence or stage of a disease in a test subject.

摘要翻译： 本发明提供了一种通过将受试者细胞的特征反应模式评估为包含在受试者的生物流体中的指标来检测异常状况或疾病状态的方法。 可以通过从已知显示特定异常状况的受试者确定应答细胞的体液或其部分的反应模式的响应模式，可选地将所述模式与由正常受试者的流体或分数引起的模式进行比较来获得特征性疾病相关模式， 识别不同的元素。 识别的元件构成特征或差异图案，然后可以用于鉴定测试对象中疾病的存在或阶段。