公开(公告)号：US07972785B2

公开(公告)日：2011-07-05

申请号：US11656389

申请日：2007-01-23

Applicant: Hui-Chu Hsieh ,  Tzu-Ling Tseng ,  Li-Jen Su ,  Chi-Ying Huang ,  Shih-Lan Hsu

Inventor： Hui-Chu Hsieh ,  Tzu-Ling Tseng ,  Li-Jen Su ,  Chi-Ying Huang ,  Shih-Lan Hsu

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2800/085

Abstract: The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.

Abstract translation: 本发明提供一种检测肝纤维化损伤（包括纤维化和/或肝硬化）的方法，通过测定生物样品来鉴别至少一种编码选自SEQ ID NO：1-SEQ ID NO：63的蛋白质的基因和人直向同源物 其中至少一个基因的差异表达表明存在肝纤维化或肝硬化。 本发明还提供了一种试剂盒，其包含通过测定由SEQ ID NO：1-SEQ ID NO：63编码的蛋白质的差异表达及其人类直向同源物来检测肝纤维化和/或肝硬化的核酸探针或抗体。

公开(公告)号：US20070184476A1

公开(公告)日：2007-08-09

申请号：US11656389

申请日：2007-01-23

Applicant: Hui-Chu Hsieh ,  Tzu-Ling Tseng ,  Li-Jen Su ,  Chi-Ying Huang ,  Shih-Lan Hsu

Inventor： Hui-Chu Hsieh ,  Tzu-Ling Tseng ,  Li-Jen Su ,  Chi-Ying Huang ,  Shih-Lan Hsu

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N33/5023 ,  G01N2800/085

Abstract: The present invention provides a method for detecting liver fibrotic injury, including fibrosis and/or cirrhosis, by assaying biological samples for differential expression of at least one gene encoding a protein chosen from SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof, wherein differential expression of at least one gene suggests the presence of liver fibrosis or cirrhosis. The invention also provides a kit containing nucleic acid probes or antibodies for detecting liver fibrosis and/or cirrhosis by assaying the differential expression of proteins encoded by SEQ ID NO: 1-SEQ ID NO: 63 and human orthologs thereof.

Abstract translation: 本发明提供一种检测肝纤维化损伤（包括纤维化和/或肝硬化）的方法，通过测定生物样品来鉴别至少一种编码选自SEQ ID NO：1-SEQ ID NO：63的蛋白质的基因和人直向同源物 其中至少一个基因的差异表达表明存在肝纤维化或肝硬化。 本发明还提供了一种试剂盒，其包含通过测定由SEQ ID NO：1-SEQ ID NO：63编码的蛋白质的差异表达及其人类直向同源物来检测肝纤维化和/或肝硬化的核酸探针或抗体。