公开(公告)号：US20090247754A1

公开(公告)日：2009-10-01

申请号：US12411111

申请日：2009-03-25

Applicant: Gail Underiner ,  Frank Gibson ,  Linli He ,  Harihara Subramanian Meera ,  Jesudoss Mercy Gnanadeepam ,  Ramanathan Saiganesh ,  Stephen R. Tudhope ,  Manouchehr Azadi-Ardakani

Inventor： Gail Underiner ,  Frank Gibson ,  Linli He ,  Harihara Subramanian Meera ,  Jesudoss Mercy Gnanadeepam ,  Ramanathan Saiganesh ,  Stephen R. Tudhope ,  Manouchehr Azadi-Ardakani

IPC: C07D221/22 ,  C07D215/00

CPC classification number: C07D221/22 ,  C07D215/22 ,  C07D215/48

Abstract: The present invention is related to the synthesis of huperzine A. The synthesis includes a variety of process steps that increase productivity, reduce safety concerns, and allow for increasing production of compounds of desired optical isomer. The inventive methods may encompass a single improved reaction step that may be incorporated into a known reaction process for synthesizing huperzine A or a derivative thereof to improve the overall reaction. The inventive methods also encompass complete synthesis methods for preparing huperzine A or a derivative thereof.

Abstract translation: 本发明涉及石杉碱甲的合成。合成包括提高生产率，减少安全性问题并允许增加所需旋光异构体化合物生产的各种方法步骤。 本发明的方法可以包括单个改进的反应步骤，其可以并入用于合成石杉碱甲或其衍生物以改善总体反应的已知反应方法中。 本发明的方法还包括制备石杉碱甲或其衍生物的完整合成方法。

公开(公告)号：US08633314B2

公开(公告)日：2014-01-21

申请号：US13404137

申请日：2012-02-24

Applicant: Stephen Bierlmaier ,  Michael Christie ,  R. Scott Field ,  R. Curtis Haltiwanger ,  Linli He ,  Martin J. Jacobs ,  Michael Kress ,  Robert E. McKean ,  Dale R. Mowrey ,  Joseph Petraitis ,  Mehran Yazdanian ,  Veronique Courvoisier

Inventor： Stephen Bierlmaier ,  Michael Christie ,  Laurent Courvoisier ,  R. Scott Field ,  R. Curtis Haltiwanger ,  Linli He ,  Martin J. Jacobs ,  Michael Kress ,  Robert E. McKean ,  Dale R. Mowrey ,  Joseph Petraitis ,  Mehran Yazdanian

IPC: C07D295/12

CPC classification number: C07D487/04

Abstract: The present invention provides alternative forms of Compound I, processes to reproducibly make them and methods of treating patients using them.

Abstract translation: 本发明提供了替代形式的化合物I，可重复制备它们的方法和使用它们治疗患者的方法。

公开(公告)号：US20120214998A1

公开(公告)日：2012-08-23

申请号：US13404137

申请日：2012-02-24

Applicant: Stephen Bierlmaier ,  Michael Christie ,  Laurent Courvoisier ,  Veronique Courvoisier ,  R. Scott Field ,  R. Curtis Haltiwanger ,  Linli He ,  Martin J. Jacobs ,  Michael Kress ,  Robert E. McKean ,  Dale R. Mowrey ,  Joseph Petraitis ,  Mehran Yazdanian

Inventor： Stephen Bierlmaier ,  Michael Christie ,  Laurent Courvoisier ,  Veronique Courvoisier ,  R. Scott Field ,  R. Curtis Haltiwanger ,  Linli He ,  Martin J. Jacobs ,  Michael Kress ,  Robert E. McKean ,  Dale R. Mowrey ,  Joseph Petraitis ,  Mehran Yazdanian

IPC: C07D295/12

CPC classification number: C07D487/04

Abstract: The present invention provides alternative forms of Compound I, processes to reproducibly make them and methods of treating patients using them.

Abstract translation: 本发明提供了替代形式的化合物I，可重复制备它们的方法和使用它们治疗患者的方法。