公开(公告)号：US09840546B2

公开(公告)日：2017-12-12

申请号：US12936164

申请日：2008-04-03

Applicant: Weidong Zhou ,  Xiaojin Liao ,  Li Sun ,  Linzhong Zhang ,  Qingsong Lu ,  Shiye Shen ,  Lishan Yang ,  Defang Zhang ,  Huihuang Lin ,  Ping Zhang

Inventor： Weidong Zhou ,  Xiaojin Liao ,  Li Sun ,  Linzhong Zhang ,  Qingsong Lu ,  Shiye Shen ,  Lishan Yang ,  Defang Zhang ,  Huihuang Lin ,  Ping Zhang

IPC: A61K38/27 ,  C07K14/00 ,  C07K14/61 ,  A61K47/60

CPC classification number: C07K14/61 ,  A61K38/27 ,  A61K47/60 ,  Y02A50/473

Abstract: The growth hormone with high biological activity modified by the double-stranded polyethylene glycol at a single site and the preparation method thereof are provided. The PEGylated growth hormone has a higher biological activity and a longer half-life than the unmodified growth hormone. The composition comprising the PEGylated growth hormone is useful in the treatment of the growth or development disorder such as growth hormone deficiency, Turner syndrome etc.