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公开(公告)号:US20100093612A1
公开(公告)日:2010-04-15
申请号:US12527603
申请日:2008-02-19
申请人: Giovanni Casiraghi , Paola Burreddu , Leonardo Pierpaolo Manzoni , Carlo Scolastico , Franca Zanardi , Lucia Battistini , Claudio Curti , Gloria Rassu , Luciana Auzzas
发明人: Giovanni Casiraghi , Paola Burreddu , Leonardo Pierpaolo Manzoni , Carlo Scolastico , Franca Zanardi , Lucia Battistini , Claudio Curti , Gloria Rassu , Luciana Auzzas
CPC分类号: C07K5/1021 , C07K5/0205
摘要: The present invention relates to novel hybrid cyclopeptide compounds embodying pyrrolidine- or piperidine-based amino acid substructures grafted onto a RGD (-Arg-Gly-Asp-) tripeptide sequence and acting as targeting ligands towards integrin receptors, intended, for example, for the treatment of altered angiogenic phenomena or for the preparation of therapeutically and/or diagnostically useful compounds; the invention also concerns a process for the synthesis of said cyclopeptides and biologically active derivatives thereof.
摘要翻译: 本发明涉及体现了接枝到RGD(-Arg-Gly-Asp-)三肽序列上的作为靶向配体的整合素受体的基于吡咯烷或哌啶的氨基酸亚结构的新的杂环环肽化合物,其旨在例如用于 治疗改变的血管发生现象或用于制备治疗和/或诊断上有用的化合物; 本发明还涉及合成所述环肽及其生物活性衍生物的方法。