公开(公告)号：US20090131624A1

公开(公告)日：2009-05-21

申请号：US12271040

申请日：2008-11-14

Applicant: MATTHEW DALE REEVES ,  DWIGHT D. WELLER

Inventor： MATTHEW DALE REEVES ,  DWIGHT D. WELLER

IPC: C07D487/04 ,  C08G73/06

CPC classification number: C07D487/04 ,  C08G73/00 ,  C08G73/06 ,  C08G79/02

Abstract: Morpholino compounds are provided having the structure: where R1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers.

Abstract translation: 提供具有以下结构的吗啉代化合物：其中R 1选自低级烷基，二（低级烷基）氨基和苯基; R2选自低级烷基，单环芳基甲基和单环（芳氧基）甲基; R3选自三芳基甲基和氢; 并且Y选自：保护的或未被保护的羟基或氨基; 氯代磷酰胺基; 以及与另一个吗啉代化合物或吗啉代低聚物的环氮的二亚磷酸连接。 这些化合物包括双重保护的吗啉鸟嘌呤（MoG）单体。 还描述了它们在吗啉低聚物的合成中的用途。

公开(公告)号：US08076476B2

公开(公告)日：2011-12-13

申请号：US12271040

申请日：2008-11-14

Applicant: Matthew Dale Reeves ,  Dwight D. Weller ,  Yongfu Li

Inventor： Matthew Dale Reeves ,  Dwight D. Weller ,  Yongfu Li

IPC: C07D413/04 ,  C07D413/14

CPC classification number: C07D487/04 ,  C08G73/00 ,  C08G73/06 ,  C08G79/02

Abstract: Morpholino compounds are provided having the structure: where R1 is selected from the group consisting of lower alkyl, di(lower alkyl)amino, and phenyl; R2 is selected from the group consisting of lower alkyl, monocyclic arylmethyl, and monocyclic (aryloxy)methyl; R3 is selected from the group consisting of triarylmethyl and hydrogen; and Y is selected from the group consisting of: a protected or unprotected hydroxyl or amino group; a chlorophosphoramidate group; and a phosphorodiamidate linkage to the ring nitrogen of a further morpholino compound or a morpholino oligomer. Such compounds include doubly protected morpholino guanine (MoG) monomers. Also described is their use in synthesis of morpholino oligomers.

Abstract translation: 提供具有以下结构的吗啉代化合物：其中R 1选自低级烷基，二（低级烷基）氨基和苯基; R2选自低级烷基，单环芳基甲基和单环（芳氧基）甲基; R3选自三芳基甲基和氢; 并且Y选自：保护的或未被保护的羟基或氨基; 氯代磷酰胺基; 以及与另一个吗啉代化合物或吗啉代低聚物的环氮的二亚磷酸连接。 这些化合物包括双重保护的吗啉鸟嘌呤（MoG）单体。 还描述了它们在吗啉低聚物的合成中的用途。