公开(公告)号：US20080003222A1

公开(公告)日：2008-01-03

申请号：US11573269

申请日：2005-07-27

申请人： Peter Altevogt ,  Daniela Gast ,  Maina Fogel

发明人： Peter Altevogt ,  Daniela Gast ,  Maina Fogel

IPC分类号： A61K31/7088 ,  A61K38/16 ,  A61K39/395 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/566

CPC分类号： C12N9/6489 ,  C07K14/70503

摘要： Described is a pharmaceutical composition comprising a compound(s) interfering with the biological activity of L1 and/or ADAM10 or their expression. Also described is the use of said compound(s) for the prevention/treatment of carcinomas like ovarian and endometrial carcinoma. Finally, the diagnosis of highly malignant forms of carcinomas which is based on the determination of the activity/expression of L1 and/or ADAM10 is described.

摘要翻译： 描述了包含干扰L1和/或ADAM10的生物学活性或其表达的化合物的药物组合物。 还描述了所述化合物用于预防/治疗诸如卵巢和子宫内膜癌的癌症的用途。 最后，描述了基于L1和/或ADAM10的活性/表达的确定的高度恶性形式的癌症的诊断。