公开(公告)号：US4537895A

公开(公告)日：1985-08-27

申请号：US500969

申请日：1983-06-03

申请人： Gyula Deak ,  Erzsebet Zara nee Kaczian ,  Lajos Gyorgy ,  Marton Fekete ,  Margit Doda ,  Andras Seregi ,  Bela Kanyicska ,  Erzsebet Toth nee Pecsi ,  Maria Horvath nee Gaal ,  Sandor Manyai ,  Frigyes Gorgenyi ,  Gyorgyi Vaszovics nee Reichmann

发明人： Gyula Deak ,  Erzsebet Zara nee Kaczian ,  Lajos Gyorgy ,  Marton Fekete ,  Margit Doda ,  Andras Seregi ,  Bela Kanyicska ,  Erzsebet Toth nee Pecsi ,  Maria Horvath nee Gaal ,  Sandor Manyai ,  Frigyes Gorgenyi ,  Gyorgyi Vaszovics nee Reichmann

IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P25/16 ,  A61P25/24 ,  C07D217/04 ,  C07D217/12 ,  C07D217/14

CPC分类号： C07D217/14 ,  C07D217/04

摘要： The invention relates to new 4-aryl-2-methyl-1,2,3,4-tetrahydro-isoquinoline derivatives of the general Formula I ##STR1## and salts thereof whereinR stands for hydrogen, lower alkyl or halogen andX represents a group of the general Formula --(CH.sub.2).sub.n --NR.sup.1 R.sup.2, --NH--R.sup.3 or --OR.sup.4, in whichR.sup.1 and R.sup.2 may be the same or different and stand for hydrogen or lower alkyl or R.sup.1 and R.sup.2 together with the adjacent nitrogen atom, they are attached to, form a 5- or 6-membered saturated heterocyclic ring which may optionally contain a further oxygen or sulfur atom or an optionally lower alkyl substituted imino group;n is an integral number 1, 2, 3 or 4;R.sup.3 stands for lower alkyl or optionally substituted phenyl andR.sup.4 is lower alkyl, halogeno lower alkyl, or phenyl lower alkyl.The compounds of the general Formula I are useful as antidepressants and antiparkinsone agents.The compounds of the general Formula I can be prepared by methods known per se.

摘要翻译： 本发明涉及通式I的新的4-芳基-2-甲基-1,2,3,4-四氢 - 异喹啉衍生物及其盐，其中R代表氢，低级烷基或卤素， X表示通式 - （CH 2）n -NR 1 R 2，-NH-R 3或-OR 4的基团，其中R 1和R 2可以相同或不同，代表氢或低级烷基或R 1和R 2与相邻的 氮原子，它们连接，形成可任选地含有另外的氧或硫原子或任选的低级烷基取代的亚氨基的5-或6-元饱和杂环; n是整数1,2,3或4; R3代表低级烷基或任意取代的苯基，R4代表低级烷基，卤代低级烷基或苯基低级烷基。 通式I的化合物可用作抗抑郁药和抗帕金森内酯剂。 通式I的化合物可以通过本身已知的方法制备。

公开(公告)号：US3946018A

公开(公告)日：1976-03-23

申请号：US439823

申请日：1974-02-05

申请人： Gyula Deak ,  Margit Doda ,  Lajos Gyorgy ,  Laszlo Hazai ,  Klara Pfeifer, deceased

发明人： Gyula Deak ,  Margit Doda ,  Lajos Gyorgy ,  Laszlo Hazai ,  Klara Pfeifer, deceased

IPC分类号： A61K31/47 ,  A61K31/472 ,  A61P25/08 ,  C07D217/24

CPC分类号： C07D217/24

摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 and R.sub.2 each represent hydrogen or a straight-chained or branched C.sub.1.sub.-3 alkyl group,R stands for hydrogen or a straight-chained or branched C.sub.1.sub.-4 alkyl group,R.sub.3 stands for hydrogen or a straight-chained or branched C.sub.1.sub.-4 alkyl group.The new compounds of formula (I) possess valuable pharmacological properties, and act, primarily, on the central nervous system. Thus they can be used in the therapy first of all as the active agents of anticonvulsive medicines.

摘要翻译： 式WHEREIN R 1和R 2的化合物各自表示氢或直链或支链C 1-3烷基，R代表氢或直链或支链C 1-4烷基，R 3代表氢或直链 或支链C 1-4烷基。