公开(公告)号：US20110183989A1

公开(公告)日：2011-07-28

申请号：US13060718

申请日：2009-08-28

申请人： Danila Branca ,  Federica Ferrigno ,  Jose Ignacio Martin Hernando ,  Philip Jones ,  Olaf Kinzel ,  Savina Malancona ,  Ester Muraglia ,  Maria Cecilia Palumbi ,  Giovanna Pescatore ,  Rita Scarpelli

发明人： Danila Branca ,  Federica Ferrigno ,  Jose Ignacio Martin Hernando ,  Philip Jones ,  Olaf Kinzel ,  Savina Malancona ,  Ester Muraglia ,  Maria Cecilia Palumbi ,  Giovanna Pescatore ,  Rita Scarpelli

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smoantagonists。 因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症 上胃肠道

公开(公告)号：US08470823B2

公开(公告)日：2013-06-25

申请号：US13060718

申请日：2009-08-28

申请人： Danila Branca ,  Federica Ferrigno ,  Jose Ignacio Martin Hernando ,  Philip Jones ,  Olaf Kinzel ,  Savina Malancona ,  Ester Muraglia ,  Maria Cecilia Palumbi ,  Giovanna Pescatore ,  Rita Scarpelli

发明人： Danila Branca ,  Federica Ferrigno ,  Jose Ignacio Martin Hernando ,  Philip Jones ,  Olaf Kinzel ,  Savina Malancona ,  Ester Muraglia ,  Maria Cecilia Palumbi ,  Giovanna Pescatore ,  Rita Scarpelli

IPC分类号： A61K31/4985

CPC分类号： C07D487/04

摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.

摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smoantagonists。 因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症 上胃肠道