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公开(公告)号:US20140288299A1
公开(公告)日:2014-09-25
申请号:US13811771
申请日:2011-07-25
IPC分类号: C12N15/10
CPC分类号: C12N15/1017 , C07H21/04 , C12N15/111 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2330/30 , C12N2310/3531
摘要: The present invention relates to a process for preparing a short oligonucleotide comprising the steps of: (i) preparing a crude mixture comprising the oligonucleotide (ii) subjecting the mixture formed in step (i) to a desalting step; wherein the process does not comprise a chromatographic purification step.
摘要翻译: 本发明涉及一种制备短寡核苷酸的方法,包括以下步骤:(i)制备包含寡核苷酸的粗混合物(ii)使步骤(i)中形成的混合物经历脱盐步骤; 其中该方法不包括色谱纯化步骤。