公开(公告)号：US09849427B2

公开(公告)日：2017-12-26

申请号：US10579449

申请日：2004-11-17

申请人： Mariko Kuroda ,  Masaya Fuke ,  Masaki Katou

发明人： Mariko Kuroda ,  Masaya Fuke ,  Masaki Katou

IPC分类号： B01D67/00 ,  A61M1/18 ,  B01D69/02 ,  B01D69/08 ,  B01D69/12 ,  B01D71/34 ,  B01D71/44 ,  B01D71/68 ,  A61M1/16

CPC分类号： B01D69/02 ,  A61M1/16 ,  B01D67/0011 ,  B01D69/08 ,  B01D69/084 ,  B01D71/34 ,  B01D71/68 ,  B01D2325/023 ,  B01D2325/04 ,  B01D2325/26

摘要： An object of the present invention is to provide a hollow fiber membrane with enhanced phosphorus-removing performance without impairing antithrombogenicity in order to inhibit in vivo accumulation of phosphate ions in living body that might cause bone metabolism disorders.The present inventors have found that a hollow fiber membrane having a specific membrane structure and a specific membrane composition possesses a very useful range for inner surface charges of the membrane. More particularly, the inventors have discovered that the above object can be achieved in a limited range in which the zeta potential on the inner surface of a hollow fiber membrane measured under given certain conditions is greater than −3.0 mV but less than 0 mV. This finding has led to the completion of the present invention.

公开(公告)号：US20070080108A1

公开(公告)日：2007-04-12

申请号：US10579449

申请日：2004-11-17

申请人： Mariko Kuroda ,  Masaya Fuke ,  Masaki Katou

发明人： Mariko Kuroda ,  Masaya Fuke ,  Masaki Katou

IPC分类号： B01D67/00

CPC分类号： B01D69/02 ,  A61M1/16 ,  B01D67/0011 ,  B01D69/08 ,  B01D69/084 ,  B01D71/34 ,  B01D71/68 ,  B01D2325/023 ,  B01D2325/04 ,  B01D2325/26

摘要： An object of the present invention is to provide a hollow fiber membrane with enhanced phosphorus-removing performance without impairing antithrombogenicity in order to inhibit in vivo accumulation of phosphate ions in living body that might cause bone metabolism disorders. The present inventors have found that a hollow fiber membrane having a specific membrane structure and a specific membrane composition possesses a very useful range for inner surface charges of the membrane. More particularly, the inventors have discovered that the above object can be achieved in a limited range in which the zeta potential on the inner surface of a hollow fiber membrane measured under given certain conditions is greater than −3.0 mV but less than 0 mV. This finding has led to the completion of the present invention.

摘要翻译： 本发明的目的是提供一种具有增强的除磷性能的中空纤维膜，而不损害抗凝血性，以抑制生物体内磷酸根离子的体内积累，这可能引起骨代谢紊乱。 本发明人已经发现，具有特定膜结构和特定膜组成的中空纤维膜对于膜的内表面电荷具有非常有用的范围。 更具体地，本发明人已经发现，在给定一定条件下测量的中空纤维膜的内表面上的ζ电位大于-3.0mV但小于0mV的有限范围内可以实现上述目的。 这一发现导致了本发明的完成。