公开(公告)号：US20100298437A1

公开(公告)日：2010-11-25

申请号：US12445820

申请日：2007-08-29

申请人： Christophe Moinard ,  Marion Jourdan ,  Stephane Walrand ,  Luc Cynober

发明人： Christophe Moinard ,  Marion Jourdan ,  Stephane Walrand ,  Luc Cynober

IPC分类号： A61K31/198 ,  A61P3/00 ,  A61P35/00

CPC分类号： A61K31/198

摘要： The invention relates to the use of L-citrulline (I) or of one of its pharmaceutically acceptable salts in the preparation of a drug for the treatment of states or undernutrition as linked to a lowering of protein synthesis within the framework of pathologies which do not result from an intestinal insufficiency.

摘要翻译： 本发明涉及L-瓜氨酸（I）或其药学上可接受的盐之一在制备用于治疗状态或营养不良的药物中的用途，与在不是的病理学框架内降低蛋白质合成有关 由肠功能不全引起。

公开(公告)号：US08846759B2

公开(公告)日：2014-09-30

申请号：US13518281

申请日：2010-12-23

申请人： Yvette Charlotte Luiking ,  George Verlaan ,  Marion Jourdan

发明人： Yvette Charlotte Luiking ,  George Verlaan ,  Marion Jourdan

IPC分类号： A61K35/20 ,  A23L1/304 ,  A23L1/305 ,  A23L1/29 ,  A61K31/70 ,  A61K35/74 ,  A61K38/17 ,  A23L1/302 ,  A23L1/308

CPC分类号： A23L1/296 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A61K31/70 ,  A61K35/74 ,  A61K38/1709

摘要： The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, which involves muscle decline, as well as to specific low-caloric high-protein nutritional compositions for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least about 12 g of proteinaceous matter which comprises at least about 80 weight % of whey protein, relative to the total proteinaceous matter, and which comprises at least about 11 weight % of leucine, relative to the total proteinaceous matter, of which at least about 20 weight % is in a free form, relative to the total leucine, (ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition which involves muscle decline in a mammal, especially an elderly mammal, wherein the nutritional composition is administered as 1 to 2 servings daily, each serving comprising between 80 and 200 kcal.

摘要翻译： 本发明涉及低热量高蛋白营养组合物用于预防或治疗涉及肌肉下降的哺乳动物的疾病或病症的用途，以及特定的低热量高蛋白营养物质 刺激哺乳动物肌肉蛋白质合成的组合物。 特别地，本发明涉及包含每100千卡的营养组合物的用途：（i）至少约12克相对于总蛋白质物质至少约80重量％的乳清蛋白质的蛋白质物质，以及哪些 相对于总蛋白质物质，其至少约11重量％的亮氨酸相对于总亮氨酸为至少约20重量％，其中至少约20重量％为游离形式，（ii）脂肪源和可消化碳水化合物源 用于预防或治疗哺乳动物，特别是老年哺乳动物中涉及肌肉衰退的疾病或病症，其中营养组合物每天以1-2份服用，每份服用包含80至200千卡。

公开(公告)号：US20130203658A1

公开(公告)日：2013-08-08

申请号：US13518281

申请日：2010-12-23

申请人： Yvette Charlotte Luiking ,  George Verlaan ,  Marion Jourdan

发明人： Yvette Charlotte Luiking ,  George Verlaan ,  Marion Jourdan

IPC分类号： A23L1/29 ,  A61K31/70 ,  A61K38/17

CPC分类号： A23L1/296 ,  A23L33/15 ,  A23L33/16 ,  A23L33/175 ,  A23L33/19 ,  A23L33/21 ,  A23L33/40 ,  A61K31/70 ,  A61K35/74 ,  A61K38/1709

摘要： The present invention relates to the use of a low-caloric high-protein nutritional composition for use in the prevention or treatment of a disease or condition in a mammal, which involves muscle decline, as well as to specific low-caloric high-protein nutritional compositions for stimulating muscle protein synthesis in a mammal. In particular, the invention relates to the use of a nutritional composition comprising per 100 kcal: (i) at least about 12 g of proteinaceous matter which comprises at least about 80 weight % of whey protein, relative to the total proteinaceous matter, and which comprises at least about 11 weight % of leucine, relative to the total proteinaceous matter, of which at least about 20 weight % is in a free form, relative to the total leucine, (ii) a source of fat and a source of digestible carbohydrates, for the prevention or treatment of a disease or condition which involves muscle decline in a mammal, especially an elderly mammal, wherein the nutritional composition is administered as 1 to 2 servings daily, each serving comprising between 80 and 200 kcal.

摘要翻译： 本发明涉及低热量高蛋白营养组合物用于预防或治疗涉及肌肉下降的哺乳动物的疾病或病症的用途，以及特定的低热量高蛋白营养物质 刺激哺乳动物肌肉蛋白质合成的组合物。 特别地，本发明涉及包含每100千卡的营养组合物的用途：（i）至少约12克相对于总蛋白质物质至少约80重量％的乳清蛋白质的蛋白质物质，以及哪些 相对于总蛋白质物质，其至少约11重量％的亮氨酸相对于总亮氨酸为至少约20重量％，其中至少约20重量％为游离形式，（ii）脂肪源和可消化碳水化合物源 用于预防或治疗哺乳动物，特别是老年哺乳动物中涉及肌肉衰退的疾病或病症，其中营养组合物每天以1-2份服用，每份服用包含80至200千卡。