公开(公告)号：US08440190B2

公开(公告)日：2013-05-14

申请号：US11180631

申请日：2005-07-14

申请人： Herman Waldmann ,  Lisa K Gilliland ,  Masahide Tone ,  Mark R Frewin ,  Louise Walsh

发明人： Herman Waldmann ,  Lisa K Gilliland ,  Masahide Tone ,  Mark R Frewin ,  Louise Walsh

IPC分类号： A61K39/00

CPC分类号： C07K16/465 ,  A61K38/00 ,  C07K16/2893 ,  C07K2317/24 ,  C07K2319/00

摘要： This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.

摘要翻译： 本发明涉及作为对抗体分子的修饰或修饰的结果与治疗性抗体相比具有降低的对抗原亲和性的抗体的抗体，该抗体是对细胞表面抗原具有亲和力的治疗性抗体的修饰形式，其中 抗体能够诱导对治疗性抗体的免疫耐受性。 本发明还涉及一种诱导对治疗性抗体的免疫耐受性的方法，其包括与治疗性抗体相比，向患者施用作为治疗性抗体的修饰形式的抗体，并且其对抗原的亲和力降低。