公开(公告)号：US5602263A

公开(公告)日：1997-02-11

申请号：US410180

申请日：1995-03-24

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14 ,  C07D317/50 ,  C07D317/70

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

摘要翻译： 描述了用于合成各种含氧化合物的新型生物催化和化学方法。 特别地，描述了合成有用的合成子12的方法，该有用的合成子12是通过在合适的条件下使被保护的二醇（丙酮酸）与二氮杂异构体反应制得的。 这种合成子可用于合成各种药学上重要的化合物，例如D-手性肌醇和D-手 - 三烯糖。 此外，公开了新颖的化合物，特别包括合成子12和由其衍生的化合物。

公开(公告)号：US5442079A

公开(公告)日：1995-08-15

申请号：US60454

申请日：1993-05-10

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D493/04

CPC分类号： C07D493/04

摘要： There are described improved processes for the synthesis of a desired lactone useful as a synthon, the improved processes comprising oxidizing a protected arene diol with permanganate and periodate or subjecting a substituted epoxydiol to periodate oxidation to yield the desired lactone.

摘要翻译： 描述了用于合成可用作合成子的所需内酯的改进方法，改进的方法包括用高锰酸盐和高碘酸盐氧化受保护的芳族二醇或使取代的环氧化物高温氧化以产生所需的内酯。

公开(公告)号：US5600014A

公开(公告)日：1997-02-04

申请号：US410477

申请日：1995-03-24

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

公开(公告)号：US5602287A

公开(公告)日：1997-02-11

申请号：US410611

申请日：1995-03-24

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

公开(公告)号：US5578738A

公开(公告)日：1996-11-26

申请号：US410467

申请日：1995-03-24

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14 ,  C07D317/70

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

公开(公告)号：US5633412A

公开(公告)日：1997-05-27

申请号：US410269

申请日：1995-03-24

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14 ,  C07C35/14

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

公开(公告)号：US5563281A

公开(公告)日：1996-10-08

申请号：US408435

申请日：1995-03-22

申请人： Tomas Hudlicky ,  Martin Mandel

发明人： Tomas Hudlicky ,  Martin Mandel

IPC分类号： C07D317/64 ,  C07C29/10 ,  C07C29/145 ,  C07C35/16 ,  C07C45/42 ,  C07C45/59 ,  C07C49/497 ,  C07D317/46 ,  C07D493/04 ,  C07D493/14 ,  C07D317/70

CPC分类号： C07D493/04 ,  C07C29/145 ,  C07C35/16 ,  C07D317/46 ,  C07D493/14 ,  C07C2101/14

摘要： There are described novel biocatalytic and chemical processes for the synthesis of various oxygenated compounds. Particularly, there are described processes for the synthesis of a useful synthon 12 made by reacting a protected diol (acetonide) with permaganate under appropriate conditions. Such synthon is useful of the synthesis of various pharmaceutically important compounds such as D-chiro-inositol and D-chiro-3-inosose. Also, there are disclosed novel compounds, including specifically the synthon 12 and compounds derived therefrom.

摘要翻译： 描述了用于合成各种含氧化合物的新型生物催化和化学方法。 特别地，描述了合成有用的合成子12的方法，该有用的合成子12是通过在合适的条件下使被保护的二醇（丙酮酸）与二氮杂异构体反应制得的。 这种合成子可用于合成各种药学上重要的化合物，例如D-手性肌醇和D-手性3-三烯糖。 此外，公开了新颖的化合物，特别包括合成子12和由其衍生的化合物。