公开(公告)号：US08217031B2

公开(公告)日：2012-07-10

申请号：US12593566

申请日：2008-03-28

申请人： Masato Matsuoka ,  Tatsuya Oyama

发明人： Masato Matsuoka ,  Tatsuya Oyama

IPC分类号： A61K31/55 ,  C07D223/16

CPC分类号： C07D491/048 ,  C07D495/04

摘要： The present invention relates to a compound represented by formula [1] or a pharmaceutically acceptable salt thereof: In formula [1], one of X and Y is CH and the other is oxygen or sulfur; R is hydrogen, etc.; Z is hydrogen, etc.; Ar is phenyl, etc.; and n is 1 or 2 and or m is 1 or 2, excluding compounds where n is 2 and m is 2 simultaneously. Also provided is a pharmaceutical composition comprising a compound of formula [1] or a pharmaceutically acceptable salt thereof as an active ingredient. The composition is usable as an agent for the prevention or treatment of depression, panic disorder, anxiety, obsessive-compulsive disorder, chronic pain, fibromyalgia, obesity, stress urinary incontinence, and overactive bladder.

摘要翻译： 本发明涉及由式[1]表示的化合物或其药学上可接受的盐：在式[1]中，X和Y之一是CH，另一个是氧或硫; R是氢等; Z是氢等; Ar是苯基等; n为1或2，m为1或2，不包括n为2，m为2的化合物。 还提供了包含式[1]化合物或其药学上可接受的盐作为活性成分的药物组合物。 该组合物可用作预防或治疗抑郁症，恐慌症，焦虑症，强迫症，慢性疼痛，纤维肌痛，肥胖，压力性尿失禁和膀胱过动症的药剂。

公开(公告)号：US20100048537A1

公开(公告)日：2010-02-25

申请号：US12593566

申请日：2008-03-28

申请人： Masato Matsuoka ,  Tatsuya Oyama

发明人： Masato Matsuoka ,  Tatsuya Oyama

IPC分类号： A61K31/55 ,  C07D491/048 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/4355 ,  A61P25/24 ,  A61P25/22 ,  A61P3/04 ,  A61P25/00

CPC分类号： C07D491/048 ,  C07D495/04

摘要： The present invention relates to a compound represented by formula [1] or a pharmaceutically acceptable salt thereof: In formula [1], one of X and Y is CH and the other is oxygen or sulfur; R is hydrogen, etc.; Z is hydrogen, etc.; Ar is phenyl, etc.; and n is 1 or 2 and or m is 1 or 2, excluding compounds where n is 2 and m is 2 simultaneously. Also provided is a pharmaceutical composition comprising a compound of formula [1] or a pharmaceutically acceptable salt thereof as an active ingredient. The composition is usable as an agent for the prevention or treatment of depression, panic disorder, anxiety, obsessive-compulsive disorder, chronic pain, fibromyalgia, obesity, stress urinary incontinence, and overactive bladder.

摘要翻译： 本发明涉及由式[1]表示的化合物或其药学上可接受的盐：在式[1]中，X和Y之一是CH，另一个是氧或硫; R是氢等; Z是氢等; Ar是苯基等; n为1或2，m为1或2，不包括n为2，m为2的化合物。 还提供了包含式[1]化合物或其药学上可接受的盐作为活性成分的药物组合物。 该组合物可用作预防或治疗抑郁症，恐慌症，焦虑症，强迫症，慢性疼痛，纤维肌痛，肥胖，压力性尿失禁和膀胱过动症的药剂。