公开(公告)号：US20100060981A1

公开(公告)日：2010-03-11

申请号：US11815976

申请日：2006-02-10

申请人： Masayo Yamauchi ,  Akihide Hibara ,  Takehiko Kitamori ,  Kazuma Mawatari ,  Manabu Tokeshi

发明人： Masayo Yamauchi ,  Akihide Hibara ,  Takehiko Kitamori ,  Kazuma Mawatari ,  Manabu Tokeshi

IPC分类号： G02B21/06

CPC分类号： G01N21/171 ,  G01N21/19 ,  G01N2021/1712

摘要： An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses.The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.

摘要翻译： 本发明的目的是提供一种圆形二色性热透镜显微镜装置，其能够识别和定量超微量的光学活性样品，并且具有比常规装置更高的灵敏度。 目的是通过将激发光和检测光照射到光学显微镜中的圆二色性热透镜显微镜装置来实现，其中检测光进入通过用激发光照射样品而形成的热透镜，并且检测样品中的物质 通过确定通过热透镜的检测光的扩散，并且其中激发光被相位调制元件调制，以便识别或定量光学异构体。