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公开(公告)号：US09243048B2
公开(公告)日：2016-01-26
申请号：US12318900
申请日：2009-01-12
申请人： Masayoshi Namba , Toshiya Tsuji
发明人： Masayoshi Namba , Toshiya Tsuji
CPC分类号： C07K14/4703 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61K48/0016 , A61K48/0058 , A61K48/0075
摘要： The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell proliferation inhibitory proteins, and the genes and the proteins are utilized as agents for diagnosis or treatment, including the genetic diagnosis of or the gene therapy of diseases such as cancer.
摘要翻译： 分离其表达在包括癌细胞的不死细胞中的表达减少或消失的基因，确定它们的DNA序列，表达基因以产生细胞增殖抑制蛋白，并且将基因和蛋白质用作诊断或治疗的试剂 ，包括癌症等疾病的遗传诊断或基因治疗。
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2.发明申请Cell proliferation inhibitory proteins and polynucleotides, antisense polynucleotides to the polynucleotides, cell proliferation inhibitors using the foregoing, cancer diagnostic agents, cancer therapeutic agents and compositions for gene therapy 有权细胞增殖抑制蛋白和多核苷酸，多核苷酸的反义多核苷酸，使用前述的细胞增殖抑制剂，癌症诊断剂，癌症治疗剂和用于基因治疗的组合物公开(公告)号：US20100204308A1
公开(公告)日：2010-08-12
申请号：US12318900
申请日：2009-01-12
申请人： Masayoshi Namba , Toshiya Tsuji
发明人： Masayoshi Namba , Toshiya Tsuji
IPC分类号： A61K31/7088 , A61P35/04
CPC分类号： C07K14/4703 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61K48/0016 , A61K48/0058 , A61K48/0075
摘要： The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell proliferation inhibitory proteins, and the genes and the proteins are utilized as agents for diagnosis or treatment, including the genetic diagnosis of or the gene therapy of diseases such as cancer.
摘要翻译： 分离其表达在包括癌细胞的不死细胞中的表达减少或消失的基因，确定它们的DNA序列，表达基因以产生细胞增殖抑制蛋白，并且将基因和蛋白质用作诊断或治疗的试剂 ，包括癌症等疾病的遗传诊断或基因治疗。
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3.发明申请Cell proliferation inhibitory proteins and polynucleotides, antisense polynucleotides to the polynucleotides, cell proliferation inhibitors using the foregoing, cancer diagnostic agents, cancer therapeutic agents and compositions for gene therapy 审中-公开细胞增殖抑制蛋白和多核苷酸，多核苷酸的反义多核苷酸，使用前述的细胞增殖抑制剂，癌症诊断剂，癌症治疗剂和用于基因治疗的组合物公开(公告)号：US20060275263A1
公开(公告)日：2006-12-07
申请号：US11434813
申请日：2006-05-17
申请人： Masayoshi Namba , Toshiya Tsuji
发明人： Masayoshi Namba , Toshiya Tsuji
IPC分类号： A61K48/00 , C12N15/861 , C12Q1/68
CPC分类号： C07K14/4703 , A61K35/76 , A61K35/761 , A61K38/00 , A61K48/00 , A61K48/0016 , A61K48/0058 , A61K48/0075
摘要： The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell proliferation inhibitory proteins, and the genes and the proteins are utilized as agents for diagnosis or treatment, including the genetic diagnosis of or the gene therapy of diseases such as cancer.
摘要翻译： 分离其表达在包括癌细胞的不死细胞中的表达减少或消失的基因，确定它们的DNA序列，表达基因以产生细胞增殖抑制蛋白，并且将基因和蛋白质用作诊断或治疗的试剂 ，包括癌症等疾病的遗传诊断或基因治疗。
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