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公开(公告)号：US20190201421A1
公开(公告)日：2019-07-04
申请号：US16297410
申请日：2019-03-08
发明人： Stefan Lukas , Angelo Lepore , Stuart Mudge
CPC分类号： A61K31/65 , A61K9/2054 , A61K9/2081 , A61K9/5042 , A61K9/5047
摘要： The disclosure provides controlled release compositions comprising tetracyclines and in some embodiments, doxycycline. The controlled release doxycycline compositions of the invention exhibit a superior dissolution profile and provide reduced side effects such as nausea and irritation.
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公开(公告)号：US20170348421A1
公开(公告)日：2017-12-07
申请号：US15623742
申请日：2017-06-15
发明人： Stuart James MUDGE , David HAYES , Stefan LUKAS
IPC分类号： A61K47/38 , A61K31/496 , A61K9/00
CPC分类号： A61K47/38 , A61K9/0053 , A61K9/4866 , A61K31/496
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
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公开(公告)号：US20160101119A1
公开(公告)日：2016-04-14
申请号：US14939936
申请日：2015-11-12
发明人： Stefan Lukas , Angelo Lepore , Stuart Mudge
CPC分类号： A61K31/65 , A61K9/0053 , A61K9/1652 , A61K9/167 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5073
摘要： The disclosure provides controlled release compositions comprising tetracyclines and in some embodiments, doxycycline. The controlled release doxycycline compositions of the invention exhibit a superior dissolution profile and provide reduce side effects such as nausea and irritation.
摘要翻译： 本公开提供包含四环素的控释组合物，在一些实施方案中为多西环素。 本发明的受控释放的强力霉素组合物显示出优异的溶出曲线并且提供减少副作用，例如恶心和刺激。
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公开(公告)号：US20160101052A1
公开(公告)日：2016-04-14
申请号：US14521998
申请日：2014-10-23
发明人： Stefan Lukas , Angelo Lepore , Stuart Mudge
CPC分类号： A61K31/65 , A61K9/0053 , A61K9/1652 , A61K9/167 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5073
摘要： The disclosure provides controlled release compositions comprising tetracyclines and in some embodiments, doxycycline. The controlled release doxycycline compositions of the invention exhibit a superior dissolution profile and provide reduce side effects such as nausea and irritation.
摘要翻译： 本公开提供包含四环素的控释组合物，在一些实施方案中为多西环素。 本发明的受控释放的强力霉素组合物显示出优异的溶出曲线并且提供减少副作用，例如恶心和刺激。
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公开(公告)号：US11638758B2
公开(公告)日：2023-05-02
申请号：US17074497
申请日：2020-10-19
发明人： Stuart James Mudge , David Hayes , Stefan Lukas
IPC分类号： A61K31/496 , A61K47/38 , A61K9/48 , A61K9/00
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
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公开(公告)号：US10806792B2
公开(公告)日：2020-10-20
申请号：US16671606
申请日：2019-11-01
发明人： Stuart James Mudge , David Hayes , Stefan Lukas
IPC分类号： A61K47/38 , A61K31/496 , A61K9/48 , A61K9/00
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
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公开(公告)号：US20190125879A1
公开(公告)日：2019-05-02
申请号：US16198645
申请日：2018-11-21
发明人： Stuart James MUDGE , David HAYES , Stefan LUKAS
IPC分类号： A61K47/38 , A61K31/496 , A61K9/00
CPC分类号： A61K47/38 , A61K9/0053 , A61K9/4866 , A61K31/496
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
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公开(公告)号：US20160263129A1
公开(公告)日：2016-09-15
申请号：US15161812
申请日：2016-05-23
发明人： Stefan Lukas , Angelo Lepore , Stuart Mudge
CPC分类号： A61K31/65 , A61K9/0053 , A61K9/1652 , A61K9/167 , A61K9/4808 , A61K9/5042 , A61K9/5047 , A61K9/5073
摘要： The disclosure provides controlled release compositions comprising tetracyclines and in some embodiments, doxycycline. The controlled release doxycycline compositions of the invention exhibit a superior dissolution profile and provide reduce side effects such as nausea and irritation.
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9.发明授权公开(公告)号：US09272046B2
公开(公告)日：2016-03-01
申请号：US14511420
申请日：2014-10-10
发明人： Stuart James Mudge , David Hayes , Stefan Lukas
IPC分类号： A61K47/38 , A61K31/496
CPC分类号： A61K47/38 , A61K9/0053 , A61K31/496
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
摘要翻译： 本公开涉及包括伊曲康唑在内的药物组合物，例如固体口服剂型，制备组合物的方法，及其用于治疗疾病的方法，包括但不限于真菌感染。
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公开(公告)号：US20210038728A1
公开(公告)日：2021-02-11
申请号：US17074497
申请日：2020-10-19
发明人： Stuart James Mudge , David Hayes , Stefan Lukas
IPC分类号： A61K47/38 , A61K31/496 , A61K9/48 , A61K9/00
摘要： The disclosure relates to, among other things, pharmaceutical compositions, such as solid oral dosage forms, comprising itraconazole, methods of making the compositions, and methods of using the same for treating disorders including, but not limited to, fungal infections.
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