公开(公告)号：US20190070191A1

公开(公告)日：2019-03-07

申请号：US16172888

申请日：2018-10-29

申请人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

发明人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

IPC分类号： A61K31/5415 ,  A61K31/549 ,  A61K31/5377 ,  A61K33/24

摘要： The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and/or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.

公开(公告)号：US10888568B2

公开(公告)日：2021-01-12

申请号：US16172888

申请日：2018-10-29

申请人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

发明人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

IPC分类号： A61K31/5415 ,  A61K31/549 ,  A61K31/519 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/5377 ,  A61K33/24

摘要： The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and/or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.

公开(公告)号：US20160120876A1

公开(公告)日：2016-05-05

申请号：US14841727

申请日：2015-09-01

申请人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

发明人： Chi-Ying Huang ,  Jane Hsiao ,  Pan-Chyr Yang ,  Meng-Hua Lee

IPC分类号： A61K31/5415 ,  A61K33/24 ,  A61K31/5377

CPC分类号： A61K31/5415 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/555 ,  A61K31/7068 ,  A61K33/24 ,  A61K2300/00

摘要： The present invention relates to use of antipsychotic phenothiazine derivative for treatment of cancer. The invention also provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating a cancer, and/or preventing or delaying cancer recurrence based on trifluoperazine. The invention further provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating cancer based on thioridazine and its enantiomers. Additionally, the invention provides a use for manufacture a medicament, a pharmaceutical composition and a method for treating KRAS mutant NSCLC comprising thioridazine.

摘要翻译： 本发明涉及抗精神病药吩噻嗪衍生物用于治疗癌症的用途。 本发明还提供了用于制备药物，药物组合物和治疗癌症的方法，和/或预防或延迟基于三氟拉嗪的癌症复发的用途。 本发明还提供了制备用于治疗基于硫利达嗪及其对映异构体的癌症的药物，药物组合物和方法的用途。 另外，本发明提供了用于制备药物，药物组合物和用于治疗包含硫利达嗪的KRAS突变NSCLC的方法的用途。