公开(公告)号：US5743854A

公开(公告)日：1998-04-28

申请号：US219183

申请日：1994-03-29

Applicant: Jon Paul Dobson ,  Heinz-Gregor Wieser ,  Michael David Fuller

Inventor： Jon Paul Dobson ,  Heinz-Gregor Wieser ,  Michael David Fuller

IPC: A61B5/04 ,  A61B5/05 ,  A61B5/0484

CPC classification number: A61B5/04009 ,  A61B5/05 ,  A61B5/4094

Abstract: A method and apparatus for evoking epileptiform activity in patients with drug resistant epilepsy, as part of a presurgical evaluation procedure are disclosed. The apparatus includes a cranial helmet, for generating a DC magnetic field of a sufficient strength to evoke epileptiform activity, and means for localizing the regions of the patient's brain where said epileptiform activity has been evoked. In the preferred embodiment, the magnetic field strength varies between 1 milliTesla and 2 milliTesla, and is generated by two generally similar coils which are coaxially separated, and which are wound on corresponding thermoplastic members to form the helmet. The desired magnetic field strength is produced at about the middle of the distance between the two coils, in general registration with the hippocampus region of the brain. In an exemplary embodiment, the localizing means includes implantable Foramen Ovale electrodes for sensing the evoked and natural epileptic firings. An EEG machine is connected to the Foramen Ovale electrodes, for recording the sensed evoked and natural epileptic firings.

Abstract translation: 公开了一种用于诱发患有耐药性癫痫患者的癫痫样活性的方法和装置，作为术前评估程序的一部分。 该装置包括用于产生具有足够强度的DC磁场以引起癫痫样活动的头盔，以及用于定位已经诱发癫痫样活动的患者脑部区域的装置。 在优选实施例中，磁场强度在1毫特斯拉和2毫特斯拉之间变化，并且由同轴分离的两个大致相似的线圈产生，并且被缠绕在相应的热塑性构件上以形成头盔。 在两个线圈之间的距离的大约中间处产生期望的磁场强度，通常与脑的海马区域对齐。 在示例性实施例中，定位装置包括用于感测诱发和自然癫痫发作的可植入孔洞孔电极。 EEG机连接到Foramen Ovale电极，用于记录感觉到的诱发和自然癫痫发作。