公开(公告)号：US20130197238A1

公开(公告)日：2013-08-01

申请号：US13809327

申请日：2011-07-10

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20180282286A1

公开(公告)日：2018-10-04

申请号：US15991776

申请日：2018-05-29

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20170320832A1

公开(公告)日：2017-11-09

申请号：US15659440

申请日：2017-07-25

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20130289283A1

公开(公告)日：2013-10-31

申请号：US13926389

申请日：2013-06-25

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

摘要翻译： 描述了用于制备式（I）的5-氨基-3-氰基-1-（2,6-二氯-4-三氟甲基苯基）-4-三氟甲基亚磺酰基 - 吡唑的改进的氧化方法。 该方法包括在强酸存在下将式（II）的5-氨基-3-氰基-1-（2,6-二氯-4-三氟甲基苯基）-4-三氟甲硫基吡唑与二氯乙酸和过氧化氢混合。

公开(公告)号：US20180155294A1

公开(公告)日：2018-06-07

申请号：US15887231

申请日：2018-02-02

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20190152921A1

公开(公告)日：2019-05-23

申请号：US16257452

申请日：2019-01-25

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20170121290A1

公开(公告)日：2017-05-04

申请号：US15408124

申请日：2017-01-17

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

公开(公告)号：US20160304467A1

公开(公告)日：2016-10-20

申请号：US15196633

申请日：2016-06-29

申请人： Anat Levin ,  Michael Grabarnick

发明人： Anat Levin ,  Michael Grabarnick

IPC分类号： C07D231/44

CPC分类号： C07D231/44

摘要： An improved oxidation process for preparing 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulphinyl-pyrazole, of formula (I) is described. The process includes admixing 5-amino-3-cyano-1-(2, 6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole of formula (II) with dichloroacetic acid and hydrogen peroxide in the presence of a strong acid.

摘要翻译： 描述了用于制备式（I）的5-氨基-3-氰基-1-（2,6-二氯-4-三氟甲基苯基）-4-三氟甲基亚磺酰基 - 吡唑的改进的氧化方法。 该方法包括在强酸存在下将式（II）的5-氨基-3-氰基-1-（2,6-二氯-4-三氟甲基苯基）-4-三氟甲硫基吡唑与二氯乙酸和过氧化氢混合。

公开(公告)号：US07078465B2

公开(公告)日：2006-07-18

申请号：US10488010

申请日：2001-08-29

申请人： Michael Grabarnick ,  Yoel Sasson

发明人： Michael Grabarnick ,  Yoel Sasson

IPC分类号： C08F112/08 ,  C07D333/02

CPC分类号： C07F9/4028 ,  C07B37/04 ,  C07C17/32 ,  C07C41/22 ,  C07C43/123 ,  C07C2527/125 ,  C07C2527/135 ,  C07C2527/138 ,  C07C22/04

摘要： The present invention provides a process for bromomethylation of organic compounds, wherein said process is a two stage process comprising of the following stages: a) reacting paraformaldehyde with hydrogen bromide and separating bis-bromomethyl ether (BBME) from the reaction mixture, and, b) reacting BBME obtained in stage (a) with an organic compound in the presence of a Lewis acid, to obtain the bromomethylated organic compound. Further provided by the present invention is a process for the preparation of 4,4′-bis-(diethylphosphonomethyl)-biphenyl (BPMB).

摘要翻译： 本发明提供一种有机化合物的溴甲基化方法，其中所述方法是包括以下步骤的两步方法：a）使多聚甲醛与溴化氢反应并从反应混合物中分离双溴甲基醚（BBME），和b ）使在步骤（a）中获得的BBME与路易斯酸存在下的有机化合物反应，得到溴甲基化的有机化合物。 本发明还提供了制备4,4'-双（二乙基膦酰基甲基） - 联苯（BPMB）的方法。