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公开(公告)号：US5897878A
公开(公告)日：1999-04-27
申请号：US963967
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5413572A
公开(公告)日：1995-05-09
申请号：US203135
申请日：1994-02-18
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US5254349A
公开(公告)日：1993-10-19
申请号：US963962
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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4.发明授权Osmotic device with delayed activation of drug delivery and complete drug release 失效渗透装置延迟激活药物递送和完全药物释放
公开(公告)号：US5800422A
公开(公告)日：1998-09-01
申请号：US700323
申请日：1996-08-08
CPC分类号： A61K9/0004 , A61K9/4808
摘要： The present invention is directed to a fluid-imbibing drug delivery device which is useful for the initial delayed delivery of an active agent formulation to a fluid environment of use, the initial delay period to startup or activation of the device being of a predetermined length of time. The delivery of the agent formulation from the dispensing device is continued until essentially all of the active agent formulation is delivered as a result of the expansion of an expansion agent in the active agent delivery chamber.
摘要翻译： 本发明涉及一种流体吸收药物递送装置，其可用于将活性剂制剂初始延迟递送至使用的流体环境，初始延迟时间为启动或启动装置的预定长度 时间。 药剂制剂从分配装置的输送继续进行，直到基本上所有的活性剂制剂由于活性剂递送室中膨胀剂的膨胀而被递送。
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公开(公告)号：US5348746A
公开(公告)日：1994-09-20
申请号：US964538
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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6.发明授权Osmotic dosage system for delivering a formulation comprising liquid carrier and drug 失效用于递送包含液体载体和药物的制剂的渗透剂量系统
公开(公告)号：US5324280A
公开(公告)日：1994-06-28
申请号：US502705
申请日：1990-04-02
IPC分类号： A61K20060101 , A61K9/00 , A61K9/22 , A61K9/52 , A61K9/66
CPC分类号： A61K9/0004
摘要： An osmotic system is disclosed for delivering a beneficial agent formulation to an environment of use. The osmotic system comprises (a) an outside semipermeable wall, (b) a middle osmotically active layer, (c) a capsule comprising a beneficial agent, and (d) a passageway for dispensing the beneficial agent from the osmotic system.
摘要翻译： 公开了用于将有益剂制剂递送到使用环境的渗透系统。 渗透系统包括（a）外部半透壁，（b）中间渗透活性层，（c）包含有益剂的胶囊，和（d）用于从渗透系统分配有益剂的通道。
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公开(公告)号：US5266332A
公开(公告)日：1993-11-30
申请号：US964162
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S.-L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5830501A
公开(公告)日：1998-11-03
申请号：US964548
申请日：1992-10-21
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. -L. Wong , Jerry D. Childers , Brian L. Barclay
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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公开(公告)号：US5200195A
公开(公告)日：1993-04-06
申请号：US804137
申请日：1991-12-06
申请人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
发明人： Liang C. Dong , Michael H. Dealey , Terry L. Burkoth , Patrick S. L. Wong , Jerry D. Childers , Brian L. Barclay
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising means for lessening the tackiness and/or irritation of the components of the dosage form to mucosal tissue. The dosage form provides means for forming in the dosage form a floc comprising a drug, which floc, when delivered from the dosage form, lessens the tackiness and/or irritation of the mucosal tissue of a warm-blooded recipient.
摘要翻译： 公开了一种剂型，其包括用于减轻剂型组分对粘膜组织的粘性和/或刺激性的方法。 剂型提供了用于在剂型中形成包含药物的絮凝物，当从剂型递送时，该絮凝剂减轻温血接受者的粘膜组织的粘性和/或刺激性。
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