公开(公告)号：US09387190B2

公开(公告)日：2016-07-12

申请号：US14439535

申请日：2013-11-01

申请人： Michael Joseph Jay

发明人： Michael Joseph Jay

IPC分类号： A61K31/216 ,  A61K47/30 ,  A61K47/44 ,  A61K47/36 ,  A61K31/245 ,  A61K9/00 ,  A61C7/12 ,  A61C19/06 ,  A61C19/08

CPC分类号： A61K31/245 ,  A61C7/125 ,  A61C19/063 ,  A61C19/08 ,  A61K9/0063

摘要： A composition and method to alleviate oral mucosal discomfort and irritation in an orthodontic patient. A wax matrix containing less that 15% analgesic/anesthetic agent such as benzocaine and excipients enhanced and extended release of the analgesic/anesthetic agent compared to known art formulations. The composition exhibited desirable aesthetic properties, was easy to apply, and the relatively lower concentration of active agent provided enhanced safety.

摘要翻译： 减轻正畸患者口腔粘膜不适和刺激的组合物和方法。 含有少于15％镇痛/麻醉剂如苯佐卡因和赋形剂的蜡基质与已知的制剂相比增强并延长了镇痛/麻醉剂的释放。 组合物显示出理想的美观性，易于应用，并且相对较低浓度的活性剂提供了增强的安全性。

公开(公告)号：US20150297550A1

公开(公告)日：2015-10-22

申请号：US14439535

申请日：2013-11-01

申请人： Michael Joseph JAY

发明人： Michael Joseph JAY

IPC分类号： A61K31/245

CPC分类号： A61K31/245 ,  A61C7/125 ,  A61C19/063 ,  A61C19/08 ,  A61K9/0063

摘要： A composition and method to alleviate oral mucosal discomfort and irritation in an orthodontic patient. A wax matrix containing less that 15% analgesic/anesthetic agent such as benzocaine and excipients enhanced and extended release of the analgesic/anesthetic agent compared to known art formulations. The composition exhibited desirable aesthetic properties, was easy to apply, and the relatively lower concentration of active agent provided enhanced safety.

摘要翻译： 减轻正畸患者口腔粘膜不适和刺激的组合物和方法。 含有少于15％镇痛/麻醉剂如苯佐卡因和赋形剂的蜡基质与已知的制剂相比增强并延长了镇痛/麻醉剂的释放。 组合物显示出理想的美观性，易于应用，并且相对较低浓度的活性剂提供了增强的安全性。

公开(公告)号：US6074674A

公开(公告)日：2000-06-13

申请号：US119099

申请日：1998-07-20

申请人： Michael Joseph Jay ,  G. Thomas Kluemper ,  Sang Hun Kim

发明人： Michael Joseph Jay ,  G. Thomas Kluemper ,  Sang Hun Kim

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/50

CPC分类号： A61K9/0063 ,  A61K9/2013 ,  A61K9/205 ,  Y10S514/817 ,  Y10S514/90 ,  Y10S514/902

摘要： The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0.2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.

摘要翻译： 本发明特别提供了可用于改善与粘膜擦伤相关的症状的制剂，特别是由于牙科矫正支架引起的症状的制剂; 口腔手术 牙周手术或其他手术。 例如，有一种配方，其包括：65至75％的微晶蜡; 5至15％非离子聚合物; 15至25％局部麻醉; 和1至5％表面活性剂，其中非离子聚合物与微晶蜡的比例不大于0.2。 优选地，对于固体局部麻醉剂，粒度小于100目筛孔的孔径。 然而，局部麻醉剂也可以是液体。 其中混合物是均匀基质的制剂是优选的。