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公开(公告)号：US08206936B2
公开(公告)日：2012-06-26
申请号：US12823104
申请日：2010-06-24
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/58 , G01N33/6878 , G06F17/16 , G06F19/24
摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
摘要翻译： 描述了基于其表位结合特征分类抗体的方法。 提供了确定不同抗体表位识别性质的方法和系统。 还提供了基于其表位识别性质聚簇抗体的数据分析方法，以及用于鉴定具有不同表位结合特征的抗体。
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公开(公告)号：US07771951B2
公开(公告)日：2010-08-10
申请号：US10309419
申请日：2002-12-02
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/58 , G01N33/6878 , G06F17/16 , G06F19/24
摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
摘要翻译： 描述了基于其表位结合特征分类抗体的方法。 提供了确定不同抗体表位识别性质的方法和系统。 还提供了基于其表位识别性质聚簇抗体的数据分析方法，以及用于鉴定具有不同表位结合特征的抗体。
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公开(公告)号：US20130085074A1
公开(公告)日：2013-04-04
申请号：US13480356
申请日：2012-05-24
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/58 , G01N33/6878 , G06F17/16 , G06F19/24
摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
摘要翻译： 描述了基于其表位结合特征分类抗体的方法。 提供了确定不同抗体表位识别性质的方法和系统。 还提供了基于其表位识别性质聚簇抗体的数据分析方法，以及用于鉴定具有不同表位结合特征的抗体。
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公开(公告)号：US20110021373A1
公开(公告)日：2011-01-27
申请号：US12823104
申请日：2010-06-24
IPC分类号： C40B30/04 , G01N33/566
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/58 , G01N33/6878 , G06F17/16 , G06F19/24
摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
摘要翻译： 描述了基于其表位结合特征分类抗体的方法。 提供了确定不同抗体表位识别性质的方法和系统。 还提供了基于其表位识别性质聚簇抗体的数据分析方法，以及用于鉴定具有不同表位结合特征的抗体。
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公开(公告)号：US07378091B2
公开(公告)日：2008-05-27
申请号：US10309762
申请日：2002-12-02
申请人： Jean Gudas , Ian Foltz , Masahisa Handa , Michael L. Gallo
发明人： Jean Gudas , Ian Foltz , Masahisa Handa , Michael L. Gallo
IPC分类号： A61K39/395 , C07K16/18 , C07K16/32
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/40 , C07K2317/21 , C07K2317/565 , C07K2317/732 , C07K2317/77
摘要： The present invention relates generally to the generation and characterization of anti-CA IX monoclonal antibodies. The invention further relates to the use of such anti-CA IX antibodies in the diagnosis and treatment of disorders associated with increased activity of CA IX, in particular, tumors such as colorectal cancer, renal cell carcinoma (RCC), cervical and other cancers of epithelial origin.
摘要翻译： 本发明一般涉及抗CA IX单克隆抗体的产生和表征。 本发明还涉及这种抗CA IX抗体在诊断和治疗与增加CA IX活性相关的疾病，特别是肿瘤如结肠直肠癌，肾细胞癌（RCC），子宫颈癌和其他癌症的肿瘤中的用途 上皮起源。
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公开(公告)号：US08568992B2
公开(公告)日：2013-10-29
申请号：US13480356
申请日：2012-05-24
IPC分类号： G01N33/53
CPC分类号： G01N33/543 , G01N33/54306 , G01N33/58 , G01N33/6878 , G06F17/16 , G06F19/24
摘要： Methods for categorizing antibodies based on their epitope binding characteristics are described. Methods and systems for determining the epitope recognition properties of different antibodies are provided. Also provided are data analysis processes for clustering antibodies on the basis of their epitope recognition properties and for identifying antibodies having distinct epitope binding characteristics.
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