公开(公告)号：US20140288084A1

公开(公告)日：2014-09-25

申请号：US14354560

申请日：2012-10-28

申请人： Craig W. Lindsley ,  P. Jeffrey Conn ,  Michael R. Woods ,  Corey R. Hopkins ,  Bruce J. Melancon ,  Michael S. Poslusney ,  Darren W. Engers

发明人： Craig W. Lindsley ,  P. Jeffrey Conn ,  Michael R. Woods ,  Corey R. Hopkins ,  Bruce J. Melancon ,  Michael S. Poslusney ,  Darren W. Engers

IPC分类号： C07D519/00 ,  C07D403/10 ,  C07D487/04 ,  C07D401/10 ,  C07D401/14 ,  C07D471/04 ,  C07D417/10

CPC分类号： C07D471/04 ,  C07D275/06 ,  C07D401/10 ,  C07D401/14 ,  C07D403/10 ,  C07D405/10 ,  C07D417/10 ,  C07D487/04 ,  C07D519/00

摘要： In one aspect, the invention relates to substituted 2-(4-heterocyclylbenzyl)isoindolin-1-one analogs compounds, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the muscarinic acetylcholine receptor M1 (mAChR M1); synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with muscarinic acetylcholine receptor dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

摘要翻译： 一方面，本发明涉及用作毒蕈碱乙酰胆碱受体M1（mAChR M1）的正变构调节剂的取代的2-（4-杂环基苄基）异二氢吲哚-1-酮类似物化合物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗与毒蕈碱性乙酰胆碱受体功能障碍相关的神经和精神疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

公开(公告)号：US08302550B1

公开(公告)日：2012-11-06

申请号：US12831580

申请日：2010-07-07

申请人： Michael R. Woods

发明人： Michael R. Woods

IPC分类号： G09F21/04 ,  B60R13/00

CPC分类号： G09F21/04

摘要： An antenna cover and topper device including a sleeve having a top end and a bottom end having a pair of V-shaped notches therein, a threaded housing disposed within the top end, a gap below the housing, a hollow cylindrical upper bushing below the gap, a lower bushing within a sleeve bottom end, a cavity disposed between the upper and lower bushings, a display member having holes aligned in upper and lower edges thereof, and a bolt removably engaging the holes and the threaded opening to secure the display member to the sleeve. A vehicle antenna engages a lower bushing lower opening, the cavity, and an upper bushing aperture with the antenna top ball secured within the gap. A clamp removably secures the antenna base top section into lower bushing.

摘要翻译： 一种天线盖和顶盖装置，包括一个具有顶端和底端的套筒，该套筒具有一对V形槽口，设置在顶端内的螺纹壳体，在壳体下方的间隙，在间隙下方的中空圆柱形上衬套 ，套筒底端内的下衬套，设置在上衬套和下套管之间的空腔，具有在其上边缘和下边缘中对齐的孔的显示构件和可拆卸地接合孔和螺纹孔的螺栓，以将显示构件固定到 袖子。 车辆天线接合下套管下开口，空腔和上衬套孔，天线顶球固定在间隙内。 夹具将天线底部顶部可拆卸地固定到下部衬套中。