公开(公告)号：US4412988A

公开(公告)日：1983-11-01

申请号：US310392

申请日：1981-10-09

申请人： Jean-Claude Gasc ,  Serge Geoffre ,  Michel Hospital ,  Jacques Laurent

发明人： Jean-Claude Gasc ,  Serge Geoffre ,  Michel Hospital ,  Jacques Laurent

IPC分类号： A61K38/00 ,  A61P25/00 ,  C07K1/04 ,  C07K7/06 ,  C07C103/52 ,  A61K37/02

CPC分类号： C07K7/06 ,  A61K38/00 ,  Y10S930/26 ,  Y10S930/27

摘要： Novel hexapeptides of the formulaCys--X--Y--D--Lys--Z Iwherein X is a sequence selected from the group consisting of Ala--Ala and Glu--His, Y is selected from the group consisting of Cys and Phe and Z is Phe when Y is Cys or Z is Cys when Y is Phe, the two Cys groups in the molecule being joined by a disulfide bridge, and their functional derivatives such as their non-toxic, pharmaceutically acceptable acid addition salts, salts with bases, esters and amides and metallic complexes thereof having an influence on the memory process and their preparation.

摘要翻译： 式Cys-XYD-Lys-Z I的新型六肽，其中X为选自Ala-Ala和Glu-His的序列，Y选自Cys和Phe，Z为Phe时，Y为 当Y为Phe时，Cys或Z为Cys，分子中的两个Cys基团通过二硫键连接，其功能衍生物如其无毒的药学上可接受的酸加成盐，与碱，酯和酰胺的盐和金属 其复合物对记忆过程及其制备有影响。