公开(公告)号：US20090216098A1

公开(公告)日：2009-08-27

申请号：US12391707

申请日：2009-02-24

申请人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index 6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index >1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 持续低于一定血红蛋白氧饱和度阈值（氧饱和度指数<1）的组织长时间（> 6小时）变得越来越脱水，最终变得明显坏死。 尽管相对于抬高前的饱和度值显着缺氧，但超过这个阈值的组织（氧饱和度指数> 1）在升高后监测期间仍然可行。 手术后立即观察到的组织氧饱和度下降的幅度与瓣组织的最终临床结果相关。 这些结果表明近红外光谱和成像监测组织氧合状态和评估重建手术后组织活力的潜力。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US06587701B1

公开(公告)日：2003-07-01

申请号：US09402348

申请日：2000-02-17

申请人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

IPC分类号： A61B500

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index 6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index>1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 持续低于一定血红蛋白氧饱和度阈值（氧饱和度指数<1）的组织长时间（> 6小时）变得越来越脱水，最终变得明显坏死。 尽管相对于抬高前的饱和度值显着缺氧，但超过这个阈值的组织（氧饱和度指数> 1）在升高后监测期间仍然可行。 手术后立即观察到的组织氧饱和度下降的幅度与瓣组织的最终临床结果相关。 这些结果表明近红外光谱和成像监测组织氧合状态和评估重建手术后组织活力的潜力。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US08060188B2

公开(公告)日：2011-11-15

申请号：US12391707

申请日：2009-02-24

申请人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US07729747B2

公开(公告)日：2010-06-01

申请号：US10319838

申请日：2002-12-16

申请人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。