公开(公告)号：US4996236A

公开(公告)日：1991-02-26

申请号：US351462

申请日：1989-05-15

申请人： Nobuto Nakamura ,  Hiroshi Satoh ,  Matsuo ,  Misael U. Esquivel

发明人： Nobuto Nakamura ,  Hiroshi Satoh ,  Matsuo ,  Misael U. Esquivel

IPC分类号： A61K31/13

CPC分类号： A61K31/13

摘要： A pharmaceutical composition for the treatment of hyperammonemia which comprises a valiolamine compound of the formula ##STR1## wherein A means an acyclic hydrocarbon group of 1 to 10 carbon atoms which may optionally be substituted by hydroxy, phenoxy, thienyl, furyl, pyridyl, chclohexyl or optionally substituted phenyl; a 5- or 6-membered cyclic hydrocarbon group which may optionally be substituted by hydroxy, hydroxymethyl, methyl or amino; or a saccharide residue or a pharmaceutically acceptable salt thereof, the use of said valiolamine compound of the formula [I]0 or a pharmaceutically acceptable salt thereof in the preparation of a medicine for the treatment of hyperammonemia, and a method for the treatment of hyperammonemia which comprises administrating a valiolamine compound of the formula [I] or a pharmaceutically acceptable salt thereof.