公开(公告)号：US07098186B2

公开(公告)日：2006-08-29

申请号：US10525717

申请日：2003-08-28

申请人： Koji Nagai ,  Masatoshi Taniguchi ,  Nobuaki Shindo ,  Yoh Terada ,  Masamichi Mori ,  Nobuaki Amino ,  Ken-ichi Suzumura ,  Isao Takahashi ,  Mitsuo Amase

发明人： Koji Nagai ,  Masatoshi Taniguchi ,  Nobuaki Shindo ,  Yoh Terada ,  Masamichi Mori ,  Nobuaki Amino ,  Ken-ichi Suzumura ,  Isao Takahashi ,  Mitsuo Amase

IPC分类号： A61K38/12 ,  C07K2/00

CPC分类号： C07K5/0205 ,  A61K38/00 ,  C07K11/00

摘要： The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.

摘要翻译： 本发明涉及一种新型化合物，其可用作预防和治疗与HDAC相关疾病，特别是肿瘤或细胞增殖性疾病的药剂。 本发明的前肽化合物或其药学上可接受的盐具有良好的HDAC抑制活性和对人癌细胞的细胞增殖的抑制活性，因此可用于治疗和改善与组蛋白乙酰化有关的疾病和病原性病症 特别是肿瘤或细胞增殖性疾病。

公开(公告)号：US20050209134A1

公开(公告)日：2005-09-22

申请号：US10525717

申请日：2003-08-28

申请人： Koji Nagai ,  Masatoshi Taniguchi ,  Nobuaki Shindo ,  Yoh Terada ,  Masamichi Mori ,  Nobuaki Amino ,  Ken-ichi Suzumura ,  Isao Takahashi ,  Mitsuo Amase

发明人： Koji Nagai ,  Masatoshi Taniguchi ,  Nobuaki Shindo ,  Yoh Terada ,  Masamichi Mori ,  Nobuaki Amino ,  Ken-ichi Suzumura ,  Isao Takahashi ,  Mitsuo Amase

IPC分类号： A61K38/00 ,  A61P35/00 ,  C07K5/02 ,  C07K11/00 ,  A61K38/12 ,  C07K5/12

CPC分类号： C07K5/0205 ,  A61K38/00 ,  C07K11/00

摘要： The present invention relates to a novel compound which is useful as an agent for prevention and treatment of diseases associated with HDAC, in particular, tumor or cell proliferative diseases. The depsipeptide compound or its pharmaceutically acceptable salt of the present invention has a good HDAC inhibitory activity and an inhibitory activity of cell proliferation against human cancer cells and, therefore, is useful in treatment and improvement of diseases and pathogenic conditions associated with histone acetylation, in particular, tumor or cell proliferative diseases.

摘要翻译： 本发明涉及一种新型化合物，其可用作预防和治疗与HDAC相关疾病，特别是肿瘤或细胞增殖性疾病的药剂。 本发明的前肽化合物或其药学上可接受的盐具有良好的HDAC抑制活性和对人癌细胞的细胞增殖的抑制活性，因此可用于治疗和改善与组蛋白乙酰化有关的疾病和病原性病症 特别是肿瘤或细胞增殖性疾病。